Abnormal regional spontaneous brain activity in major depressive disorder with obesity comorbidity: A resting-state functional magnetic resonance imaging study

Figure 1 Brain regions showing differences among the healthy control, obesity, major depressive disorder, and comorbid major depressive disorder-obesity groups. A: Left middle temporal gyrus; B: Right cuneus; C: Left precuneus; D: Left thalamus. Corrected for multiple comparisons using family-wise error rate cluster-wise corrected. MDD: Major depressive disorder; HC: Healthy control; OB: Obesity; Cuneus.R: Cuneus right; Precuneus.L: Precuneus left; Thalamus.L: Thalamus left; Gyrus.L: Gyrus left. ^aP < 0.05, ^bP < 0.01, and ^cP < 0.001.

Figure 2 The Person correlation between regional homogeneity value of the differential brain areas and clinical features. Green: Healthy control group; Orange color: Obesity group; Blue color: Major depressive disorder group; Red color: Major depressive disorder-obesity group. BASR: Behavioral activation system-reward responsiveness; BASD: Behavioral activation system-drive; BASF: Behavioral activation system-fun seeking; BIS: Behavioral inhibition/system; MTGL: Left middle temporal gyrus; Cuneus.R: Cuneus right; Precuneus.L: Precuneus left; Thalamu.L: Thalamus left. ^aP < 0.05, ^bP < 0.01, and ^cP < 0.001.