Sustained anxiolytic and antidepressant effects of botulinum toxin A in blepharospasm patients beyond motor symptom control

Figure 1 Schematic representation of botulinum toxin A injection muscle. ①: Orbicularis oculi; ②: Procerus; ③: Corrugator.

Figure 2 Flow diagram describing the study population, number included and excluded. BoNT-A: Botulinum toxin A; BEB: Benign essential blepharospasm.

Figure 3 Heat map of correlation between botulinum toxin A therapy and Jankovic Rating Scale, Blepharospasm Disability Index, Self-rating Anxiety Scale, Hamilton Anxiety Scale, Self-rating Depression Scale and Hamilton Depression Scale total and their subscale scores in a whole group and subgroups. ^aP < 0.05, N: No significance. BoNT-A: Botulinum toxin A; SAS: Self-rating Anxiety Scale; HAMA: Hamilton Anxiety Scale; SDS: Self-rating Depression Scale; HAMD: Hamilton Depression Scale; JRS: Jankovic Rating Scale; BSDI: Blepharospasm Disability Index.