Preoperative butyrylcholinesterase activity and risk of postoperative delirium: A meta-analysis

Figure 1 Flowchart of database search and study inclusion. POD: Postoperative delirium.

Figure 2 Forest plots for the meta-analysis. A and B: Forest plots for the meta-analysis of difference of preoperative serum butyrylcholinesterase activity between adult patients with and without the development of postoperative delirium (POD). A: Overall meta-analysis; B: Subgroup analysis according to follow-up duration; C-E: Forest plots for the meta-analysis of association between preoperative serum butyrylcholinesterase activity and risk of POD; C: Overall meta-analysis for the odds ratio for POD per 100 unit-increment of preoperative serum butyrylcholinesterase activity; D: Subgroup analysis according to follow-up duration; E: Subgroup analysis according to the analytic models; F-H: Forest plots for the meta-analyses of association between preoperative serum acetylcholinesterase (AChE) activity and risk of POD; F: Meta-analysis of difference of preoperative AChE activity; G: Subgroup analysis of difference of preoperative AChE activity according to follow-up duration; H: Overall meta-analysis for the odds ratio for POD per 1 unit-increment of preoperative serum AChE activity. POD: Postoperative delirium; CI: Confidence interval; AChE: Acetylcholinesterase.

Figure 3 Funnel plots for estimating potential publication biases underlying the meta-analyses. A: Funnel plots for the meta-analysis of difference in serum butyrylcholinesterase activity; B: Funnel plots for the meta-analysis of odds ratio for serum butyrylcholinesterase activity; C: Funnel plots for the meta-analysis of difference in serum acetylcholinesterase activity; D: Funnel plots for the meta-analysis of odds ratio for serum acetylcholinesterase activity. SE: Standard error; SMD: Standardized mean difference; OR: Odds ratio.