Glymphatic system dysfunction in alcohol use disorder: Current understanding and future directions

doi:10.5498/wjp.v15.i10.107936

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Oct 19, 2025 (publication date) through Oct 22, 2025

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Oct 19, 2025; 15(10): 107936
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.107936

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Figure 1 The glymphatic system in healthy individuals and alcohol use disorder patients. AQP4: Aquaporin 4; AUD: Alcohol use disorder; CSF: Cerebrospinal fluid; HIF-1α: Hypoxia-inducible factor-1 alpha; iNOS: Inducible nitric oxide synthase; ISF: Interstitial fluid; NF-κB: Nuclear factor kappa B; NLRP3: NOD-like receptor protein 1.

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Figure 2 Pathogenic mechanism and confounding factor in alcohol-induced glymphatic dysfunction. AQP4: Aquaporin 4.

Citation: Lin JY, Zhang HB, Luo L, Li RJ, Wang XG. Glymphatic system dysfunction in alcohol use disorder: Current understanding and future directions. World J Psychiatry 2025; 15(10): 107936
URL: https://www.wjgnet.com/2220-3206/full/v15/i10/107936.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i10.107936