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World J Psychiatry. Sep 19, 2026; 16(9): 123600
Published online Sep 19, 2026. doi: 10.5498/wjp.123600
Published online Sep 19, 2026. doi: 10.5498/wjp.123600
Associations between multidimensional sleep health and inflammatory bowel disease onset and activity: A systematic review of the RU-SATED framework
Li-Ji Chen, Jin-Xin Li, Jia-Xuan Li, Wei Wei, College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan 430061, Hubei Province, China
Li-Ji Chen, Jin-Xin Li, Jia-Xuan Li, Zheng-Qi Huang, Han Jiang, Xian-Jun Rao, Guo-Dong Huang, Xiao-Lan Su, Tao Zhang, Wei Wei, Department of Gastroenterology, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China
Co-corresponding authors: Tao Zhang and Wei Wei.
Author contributions: Chen LJ and Wei W designed the study; Chen LJ performed the literature search, data extraction, and drafted the initial manuscript; Chen LJ and Li JX performed the literature screening and data management; Li JX, Huang ZQ, and Jiang H performed data synthesis; Rao XJ, Huang GD, and Su XL performed data verification; Wei W and Zhang T revised, supervised, and approved the final manuscript, and they contributed equally to this manuscript as co-corresponding authors. All authors have read and approved the final manuscript.
AI contribution statement: Portions of this manuscript were edited using DeepSeek solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript. We confirm that no AI tools were used for study design, data analysis, result interpretation, or figure generation.
Supported by National Pilot Program for the Collaboration of Traditional Chinese and Western Medicine on Major and Difficult Diseases, No. Guo Zhong Yi Yao Ban Yi Zheng Fa[2018]No. 3; the Enhanced Construction Program for Clinical Collaboration of Traditional Chinese and Western Medicine on Major and Difficult Diseases, No. ZDYN-2024-B-024; Beijing Medical and Health Collaborative Project for High-Quality Research and Development of Traditional Chinese Medicine, No. zyygzl-2026-004; and the Special Project of Self-Selected Topics of Wangjing Hospital, China Academy of Chinese Medical Sciences, No. WJYY-ZZXT-2025-35.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Wei Wei, MD, Chief Physician, Principal Investigator, Professor, Department of Gastroenterology, Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6 South Middle Ring Road, Wangjing, Chaoyang District, Beijing 100102, China. sxxtyy@sina.com
Received: May 25, 2026
Revised: June 28, 2026
Accepted: July 28, 2026
Published online: September 19, 2026
Processing time: 93 Days and 19.4 Hours
Revised: June 28, 2026
Accepted: July 28, 2026
Published online: September 19, 2026
Processing time: 93 Days and 19.4 Hours
Core Tip
Core Tip: Sleep disturbance is a highly prevalent comorbidity in inflammatory bowel disease that affects disease course. This study systematically evaluated multidimensional sleep indicators in relation to disease onset and activity of inflammatory bowel disease. It reveals that short sleep increases disease risk, yet objectively measured sleep duration does not differ between active and inactive stages. However, substantial methodological heterogeneity precludes definitive conclusions for most sleep dimensions. High-quality, standardized prospective studies are needed to clarify these associations and inform clinical management.