Letter to the Editor: Insight into the nonlinear association between thyroid-stimulating hormone and suicide risk in first-episode major depressive disorder

doi:10.5498/wjp.120652

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Sep 19, 2026; 16(9): 120652
Published online Sep 19, 2026. doi: 10.5498/wjp.120652

Letter to the Editor: Insight into the nonlinear association between thyroid-stimulating hormone and suicide risk in first-episode major depressive disorder

Takahiko Nagamine

Takahiko Nagamine, Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Bunkyou 113-8510, Yamaguchi, Japan

Author contributions: All aspects of this work were carried out by the Nagamine T.

Conflict-of-interest statement: The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Corresponding author: Takahiko Nagamine, Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Bunkyou 113-8510, Yamaguchi, Japan. tnagamine@outlook.com

Received: March 5, 2026
Revised: April 10, 2026
Accepted: July 14, 2026
Published online: September 19, 2026
Processing time: 173 Days and 1.9 Hours

Core Tip

Core Tip: Deng et al identify a TSH threshold of 5.43 μIU/mL as a significant predictor of suicide attempts in first-episode drug-naïve-major depressive disorder (MDD) patients. However, to translate these findings into clinical practice, researchers must account for the biological reality that hypothyroidism and MDD phenotypes differ significantly by sex. Additionally, the relationship between thyroid-stimulating hormone and suicide should be interpreted within the broader context of metabolic health, as thyroid function and lipid/glucose metabolism are physiologically intertwined and collectively influence neurobiological vulnerability to self-harm.