Takotsubo syndrome: A review of psychobiological mechanisms and clinical practice interventions

doi:10.5498/wjp.120218

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Sep 19, 2026; 16(9): 120218
Published online Sep 19, 2026. doi: 10.5498/wjp.120218

Takotsubo syndrome: A review of psychobiological mechanisms and clinical practice interventions

Shu-Yi Lang, Fei Xia

Shu-Yi Lang, Department of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China

Fei Xia, Department of Cardiology, People’s Hospital of China Medical University (Liaoning Provincial People’s Hospital), Shenyang 110016, Liaoning Province, China

Author contributions: Lang SY contributed to the writing and editing of the manuscript; Lang SY and Xia F contributed to the literature search, designed the overall concept and outline of the manuscript; and all authors have read and approve the final manuscript.

AI contribution statement: DeepL was used for language polishing and translation.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Fei Xia, PhD, Associate Professor, Department of Cardiology, People’s Hospital of China Medical University (Liaoning Provincial People’s Hospital), No. 3 Wenyi Road, Shenhe District, Shenyang 110016, Liaoning Province, China. xf19870421@126.com

Received: March 13, 2026
Revised: April 13, 2026
Accepted: June 9, 2026
Published online: September 19, 2026
Processing time: 163 Days and 21.7 Hours

Core Tip

Core Tip: Takotsubo cardiomyopathy is a stress-induced cardiac condition with significant psychobiological underpinnings. This review synthesizes evidence on the role of psychological factors, including anxiety and post-traumatic stress disorder, in Takotsubo cardiomyopathy pathogenesis and prognosis. It highlights diagnostic approaches integrating imaging and psychological assessments, and evaluates psychological interventions such as cognitive behavioral therapy and group support, which may improve outcomes. Ongoing controversies and future directions for personalized treatment are discussed, emphasizing the need for multidisciplinary management of this mind-heart disorder.