Wu CC, Sun WH, Yang QQ, Xue L, Zhao WD. Anxiety-depression comorbidity prevalence in type 2 diabetes mellitus and correlation with insulin resistance. World J Psychiatry 2026; 16(9): 119917 [DOI: 10.5498/wjp.119917]
Corresponding Author of This Article
Wen-Di Zhao, MM, Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Longzihu District, Bengbu 233030, Anhui Province, China. wendy1071@163.com
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Psychology
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research-article
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Wu CC, Sun WH, Yang QQ, Xue L, Zhao WD. Anxiety-depression comorbidity prevalence in type 2 diabetes mellitus and correlation with insulin resistance. World J Psychiatry 2026; 16(9): 119917 [DOI: 10.5498/wjp.119917]
World J Psychiatry. Sep 19, 2026; 16(9): 119917 Published online Sep 19, 2026. doi: 10.5498/wjp.119917
Anxiety-depression comorbidity prevalence in type 2 diabetes mellitus and correlation with insulin resistance
Chen-Chen Wu, Wei-Hua Sun, Qing-Qing Yang, Li Xue, Wen-Di Zhao
Chen-Chen Wu, Wei-Hua Sun, Qing-Qing Yang, Li Xue, Wen-Di Zhao, Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233030, Anhui Province, China
Author contributions: Wu CC designed the research and wrote the first manuscript; Wu CC, Sun WH, Yang QQ, Xue L, and Zhao WD contributed to conceiving the research and analyzing data; Wu CC and Zhao WD conducted the analysis and provided guidance for the research; and all authors reviewed and approved the final manuscript.
AI contribution statement: We have never used AI tools in writing and editing this article.
Institutional review board statement: This study was approved by the Ethic Committee of the First Affiliated Hospital of Bengbu Medical University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Corresponding author: Wen-Di Zhao, MM, Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Longzihu District, Bengbu 233030, Anhui Province, China. wendy1071@163.com
Received: April 14, 2026 Revised: May 14, 2026 Accepted: June 10, 2026 Published online: September 19, 2026 Processing time: 131 Days and 22.1 Hours
Core Tip
Core Tip: This study highlights the substantial clinical burden of psychological symptoms in patients with type 2 diabetes mellitus, emphasizing that comorbid anxiety and depression are significantly associated with aggravated metabolic dysfunction. Those with concurrent anxiety and depression had worse glycemic control and greater lipid disturbances than individuals with either or no psychological symptoms. Notably, this comorbidity could independently predict severe insulin resistance, a condition featuring Homeostasis Model Assessment of insulin resistance elevation and Homeostasis Model Assessment of insulin sensitivity reduction. These findings suggest an amplified adverse effect of anxiety-depression comorbidity on insulin sensitivity, underscoring the urgency and necessity of metabolic-mental health integrated screening strategies to improve overall outcomes for type 2 diabetes mellitus patients.
