Comprehensive psychological and neurological rehabilitation for post-stroke depression: A retrospective comparative study with biomarker exploration
Shan-Zhong Yan, Song Chai, Department of Rehabilitation Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Zeng-Yan Hu, Department of Emergency, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China
Hong-Ying Zhou, Department of Medical Psychology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Co-first authors: Shan-Zhong Yan and Zeng-Yan Hu.
Author contributions: Yan SZ and Hu ZY contributed equally as co-first authors; Yan SZ was responsible for study conception, rehabilitation program coordination, data collection, statistical analysis, and manuscript drafting; Hu ZY contributed to study design, patient enrollment, and biomarker data acquisition; Zhou HY designed and supervised the psychological rehabilitation protocols and reviewed the manuscript; Chai S conceived the research framework, supervised all clinical procedures, interpreted results, and revised the manuscript; all authors approved the final version.
AI contribution statement: The authors declare that no artificial intelligence tools were used in the preparation of this manuscript, including study design, data collection, data analysis, interpretation of results, manuscript writing, or language editing. The authors assume full responsibility for the integrity, accuracy, originality, and scientific validity of the manuscript and all submitted materials.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (approval No. 2026SQ461). The study was conducted in accordance with the Declaration of Helsinki.
Informed consent statement: The requirement for written informed consent was waived by the Ethics Committee of Shanghai General Hospital because of the retrospective nature of the study and the use of de-identified clinical data.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request. No additional data are available.
Corresponding author: Song Chai, MD, Attending Physician, Department of Rehabilitation Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Hongkou District, Shanghai 200080, China.
15800452862@163.com
Received: May 9, 2026
Revised: June 24, 2026
Accepted: July 1, 2026
Published online: August 19, 2026
Processing time: 68 Days and 23.3 Hours
