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World J Psychiatry. Aug 19, 2026; 16(8): 122295
Published online Aug 19, 2026. doi: 10.5498/wjp.122295
Published online Aug 19, 2026. doi: 10.5498/wjp.122295
Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients
Xin Hu, Department of Clinical Laboratory Medicine, Dianjiang General Hospital, Chongqing 408300, China
Jin Tao, Department of Geriatrics, Traditional Chinese Medicine Hospital Dianjiang Chong
Yun-Li Jiang, Department of Psychiatry and Psychology, Dianjiang General Hospital, Chong
Kai Liu, Department of Clinical Laboratory and Transfusion Medicine, Traditional Chinese Medicine Hospital Dianjiang Chongqing, Chongqing 408300, China
Author contributions: Hu X contributed to conceptualization, study design, data collection, and manuscript drafting; Tao J contributed to patient recruitment, clinical data acquisition, and interpretation of results; Jiang YL contributed to psychological assessment of anxiety and depression, and data analysis; Liu K contributed to laboratory detection of serum inflammatory factors and p-tau181, statistical analysis, manuscript review and editing, and overall supervision as corresponding author. All authors have read and approved the final manuscript.
AI contribution statement: The authors used KIMI 2.6 solely for language polishing to improve the clarity and readability of the manuscript; no AI was involved in content generation, data analysis, study design, result interpretation, or image creation.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Traditional Chinese Medicine Hospital Dianjiang Chongqing (approval No. CZ20240228), Date: January 20, 2024). All procedures were conducted in accordance with the Declaration of Helsinki.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author (liukai891229@163.com) upon reasonable request.
Corresponding author: Kai Liu, Department of Clinical Laboratory and Transfusion Medicine, Traditional Chinese Medicine Hospital Dianjiang Chongqing, No. 502 Gongnong Road, Guixi Street, Chongqing 408300, China. liukai891229@163.com
Received: May 19, 2026
Revised: June 25, 2026
Accepted: July 20, 2026
Published online: August 19, 2026
Processing time: 71 Days and 22.4 Hours
Revised: June 25, 2026
Accepted: July 20, 2026
Published online: August 19, 2026
Processing time: 71 Days and 22.4 Hours
Core Tip
Core Tip: Anxiety and depression are common neuropsychiatric complications that markedly worsen the prognosis, as well as the quality of life in patients with Alzheimer’s disease. This study uncovers that the predictive value for anxiety and depression is improved by combining serum inflammatory markers (interleukin-6 and tumor necrosis factor alpha) with p-tau181 instead of individual biomarkers. These findings highlight the importance of comprehensive biomarker assessment as part of standard of care in Alzheimer’s disease to identify at-risk patients for early treatment.