Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Psychiatry. Aug 19, 2026; 16(8): 121207
Published online Aug 19, 2026. doi: 10.5498/wjp.121207
Published online Aug 19, 2026. doi: 10.5498/wjp.121207
Mismatch negativity as a marker for evaluating overall neurocognitive impairment following postconcussion syndrome
Jun-Jie Wang, Judicial Appraisal Institute, Affiliated Mental Health Center and Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310013, Zhejiang Province, China
Wen-Ye Wu, Kai-Jie Fang, Juan Yan, Quality Control Office, Affiliated Mental Health Center and Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310013, Zhejiang Province, China
Fu-Gang Luo, Intensive Care Unit, Affiliated Mental Health Center and Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310013, Zhejiang Province, China
Hao-Zhe Li, Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China
Co-corresponding authors: Fu-Gang Luo and Hao-Zhe Li.
Author contributions: Wang JJ and Li HZ performed conceptualization, methodology, review and editing of manuscript, and funding acquisition; Wang JJ, Wu WY, Fang KJ, and Luo FG did data curation; Wang JJ, Wu WY, Fang KJ, and Yan J did investigation; Wang JJ wrote the original draft; Luo FG and Li HZ contributed equally as co-corresponding authors. All authors approved the final version to publish.
AI contribution statement: No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions.
Supported by Open Project of the Academy of Forensic Science, No. KF202115; National Key R&D Program of China, No. 2022YFC3302001; National Natural Science Foundation of China, No. 81801881; and Science and Technology Committee Shanghai Municipality, No. 20DZ1200300, No. 21DZ2270800, and No. 19DZ2292700.
Institutional review board statement: The studies involving humans were approved by the Ethics Committee of Hangzhou Seventh People’s Hospital, No. 2021-047.
Informed consent statement: The participants provided their written informed consent to participate in this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Corresponding author: Hao-Zhe Li, Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, No. 1347 Guangfuxi Road, Putuo District, Shanghai 200063, China.
Received: March 19, 2026
Revised: May 19, 2026
Accepted: June 26, 2026
Published online: August 19, 2026
Processing time: 121 Days and 4.3 Hours
Revised: May 19, 2026
Accepted: June 26, 2026
Published online: August 19, 2026
Processing time: 121 Days and 4.3 Hours
Core Tip
Core Tip: Postconcussion syndrome (PCS) can result in long-term cognitive impairment, impacting daily function and social interactions. Despite its prevalence, effective evaluation methods for PCS-related neurocognitive dysfunction remain limited. Patients with PCS experience social dysfunction and personality changes. Mismatch negativity amplitude in the prefrontal region correlates with social dysfunction and personality changes, with smaller amplitudes indicating more severe social dysfunction and personality changes. Mismatch negativity may therefore serve as a potential indicator for assessing the symptoms of PCS.