Fibroblast growth factor receptor 1: Bridge to understanding mental disorders

doi:10.5498/wjp.118781

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Aug 19, 2026; 16(8): 118781
Published online Aug 19, 2026. doi: 10.5498/wjp.118781

Fibroblast growth factor receptor 1: Bridge to understanding mental disorders

Fei Fan, Bo Wang, Zi-Lin Chen, Wei-Feng Li, Fei Han

Fei Fan, Bo Wang, Zi-Lin Chen, Wei-Feng Li, Fei Han, Department of Paediatrics, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

Author contributions: Fan F and Wang B performed experimental operations; Fan F, Chen ZL and Han F led analysis and writing of the manuscript; Li WF and Han F supervised the research; and all authors read and approved the final manuscript.

AI contribution statement: AI tools (specifically Paperpal) were used solely for linguistic refinement and formatting assistance. No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions. All AI-generated outputs were critically reviewed and revised by the authors. The entire content of the answering-reviewers was written by myself based on my understanding of the reviewers’ comments and our original research. No portion was AI-generated.

Supported by the Fundamental Research Funds for the Central Public Welfare Research Institutes, No. ZZ17-XRZ-043.

Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.

Corresponding author: Fei Han, Professor, Department of Paediatrics, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China. hf4383@126.com

Received: January 12, 2026
Revised: March 13, 2026
Accepted: May 11, 2026
Published online: August 19, 2026
Processing time: 189 Days and 21.4 Hours

Core Tip

Core Tip: This review establishes fibroblast growth factor receptor 1 (FGFR1) as a central signaling integrator in mental disorders, moving beyond its traditional developmental roles. We highlight novel mechanisms including dynamic heteroreceptor complex formation with neurotransmitter receptors and essential neuron-glia communication, through which FGFR1 regulates synaptic and circuit plasticity. These insights directly link FGFR1 pathway dysregulation to the pathophysiology of depression and schizophrenia, positioning it as a compelling and druggable target for next-generation therapeutics.