Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Psychiatry. Aug 19, 2026; 16(8): 117931
Published online Aug 19, 2026. doi: 10.5498/wjp.117931
Published online Aug 19, 2026. doi: 10.5498/wjp.117931
Fluoxetine plus psychological intervention for chemotherapy-managed colon cancer patients: Impact on mood and influencing factors
Xiao-Xia Zhu, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
Shan Zhao, Qin Xu, Lin-Xia Xu, Ye-Jiang Zhou, Department of Gastrointestinal Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
Rui Tang, Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
Dai-Ying Zhang, Operation Room, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
Author contributions: Zhu XX designed the research and wrote the first manuscript; Zhu XX, Zhao S, Xu Q, Xu LX, Zhou YJ and Zhang DY contributed to conceiving the research and analyzing data; Zhu XX and Tang R conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of The Affiliated Hospital of Southwest Medical University, No. 2024-124.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: No additional data are available.
Corresponding author: Dai-Ying Zhang, Operation Room, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Jiangyang District, Luzhou 646000, Sichuan Province, China. zhangdaiying202112@163.com
Received: February 6, 2026
Revised: March 31, 2026
Accepted: April 29, 2026
Published online: August 19, 2026
Processing time: 165 Days and 23.4 Hours
Revised: March 31, 2026
Accepted: April 29, 2026
Published online: August 19, 2026
Processing time: 165 Days and 23.4 Hours
Core Tip
Core Tip: This study aimed to investigate the effects of fluoxetine combined with psychological intervention on mood in chemotherapy-treated colon cancer patients and explore associated determinants. Multidimensional assessment indicates that the combined therapy provides significant clinical benefits, including improvement of adverse mood, modulation of serum neurotransmitters, and enhancement of quality-of-life, without increasing the incidence of adverse events. Further analysis suggests that this combined approach may reduce the risk of inadequate mood improvement in this population.