Letter to the Editor: Adolescent mental health in transition - bridging neurobiological insights and modifiable risk factors for anxiety and depression

doi:10.5498/wjp.v16.i8.116190

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Aug 19, 2026; 16(8): 116190
Published online Aug 19, 2026. doi: 10.5498/wjp.v16.i8.116190

Letter to the Editor: Adolescent mental health in transition - bridging neurobiological insights and modifiable risk factors for anxiety and depression

Devlina Ghosh

Devlina Ghosh, Department of Biochemistry, Saraswati Dental College and Hospital, Lucknow 226028, Uttar Pradesh, India

Author contributions: Ghosh D designed the overall concept and outline of the manuscript, contributed to the discussion and design of the manuscript, and contributed to the writing and editing of the manuscript, illustration, and review of the literature. Author has read and agreed to the submitted version of the manuscript.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Corresponding author: Devlina Ghosh, PhD, Assistant Professor, Department of Biochemistry, Saraswati Dental College and Hospital, 233 Tiwariganj, Ayodhya Road, Lucknow 226028, Uttar Pradesh, India. ghoshdevlin6@gmail.com

Received: November 4, 2025
Revised: December 18, 2025
Accepted: January 26, 2026
Published online: August 19, 2026
Processing time: 255 Days and 22.9 Hours

Core Tip

Core Tip: Yang et al’s large adolescent cohort suggests that functional constipation reflects gut-brain axis disruption associated with increased anxiety and depression risk. This letter integrates emerging evidence indicating that gut dysbiosis, altered microbial metabolites, systemic inflammation, microglial activation, and reduced brain-derived neurotrophic factor-mediated neuroplasticity converge on mood regulation. It further underscores the need for longitudinal, biomarker-informed studies and scalable school-based interventions targeting diet, lifestyle, and microbiome-modulating strategies to enable precision prevention in youth mental health.