Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Psychiatry. Jul 19, 2026; 16(7): 118260
Published online Jul 19, 2026. doi: 10.5498/wjp.118260
Published online Jul 19, 2026. doi: 10.5498/wjp.118260
Anxiety-like behaviors increased in juvenile rats in the streptozotocin-induced diabetes model during the early stage
Özlem Özcanlı Çay, Faculty of Medicine Department of Pediatrics, Balıkesir University, Balikesir 100145, Türkiye
Hasan Çalışkan, Department of Physiology, School of Medicine, Department of Physiology, Faculty of Medicine, Balıkesir University, Balikesir 10145, Türkiye
Author contributions: Çalışkan H conducted the animal experiments; Özcanlı Çay Ö and Çalışkan H designed the study, analyzed the data and wrote the manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Balıkesir University, approval No. 2025-5/27.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data supporting this study’s findings are available from the corresponding author upon reasonable request.
Corresponding author: Hasan Çalışkan, PhD, Associate Professor, Department of Physiology, School of Medicine, Department of Physiology, Faculty of Medicine, Balıkesir University, Çağış Campus, AltıEylül, Balikesir 10145, Türkiye. hasan.caliskan@balikesir.edu.tr
Received: December 28, 2025
Revised: February 12, 2026
Accepted: March 30, 2026
Published online: July 19, 2026
Processing time: 180 Days and 12.7 Hours
Revised: February 12, 2026
Accepted: March 30, 2026
Published online: July 19, 2026
Processing time: 180 Days and 12.7 Hours
Core Tip
Core Tip: In this study, the relationship between hyperglycemia and anxiety-like behaviors in a streptozotocin-induced diabetes model was investigated in juvenile rats. An increase in anxiety-like behaviors and a decrease in exploratory behaviors were observed in juvenile rats during the early stages of diabetes. Both behavioral changes were correlated with hyperglycemia.