Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Psychiatry. Jul 19, 2026; 16(7): 117216
Published online Jul 19, 2026. doi: 10.5498/wjp.117216
Published online Jul 19, 2026. doi: 10.5498/wjp.117216
Effects of phototherapy plus agomelatine on efficacy, negative emotions, and neurotransmitter levels in elderly patients with depressive disorders
Ping-Jing Jiang, Shu-Wei Hu, Chun-Mei Liao, Jing-Jing Peng, Sheng-Jian Liang, Xue Cheng, Department of Psychiatry, Chongqing Mental Health Center, Chongqing 401147, China
Author contributions: Jiang PJ, Hu SW, and Cheng X designed the study and were involved in the data acquisition and writing of this article; Liao CM, Peng JJ, and Liang SJ contributed to the analysis of the manuscript; and all authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Chongqing Mental Health Center (No. 2024-011).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items..
Data sharing statement: No additional data are available.
Corresponding author: Xue Cheng, Associate Chief Physician, Department of Psychiatry, Chongqing Mental Health Center, No. 102 Jinzi Mountain, Jiangbei District, Chongqing 401147, China. chengxue000331@126.com
Received: January 23, 2026
Revised: March 2, 2026
Accepted: April 8, 2026
Published online: July 19, 2026
Processing time: 156 Days and 8.1 Hours
Revised: March 2, 2026
Accepted: April 8, 2026
Published online: July 19, 2026
Processing time: 156 Days and 8.1 Hours
Core Tip
Core Tip: Drug therapy, psychotherapy, and combined drug-psychological therapy are available treatment options for elderly patients with depressive disorders; however, therapeutic efficacy remains suboptimal. This study evaluated phototherapy combined with agomelatine in elderly patients with depressive disorders. The findings indicate that the combined therapy demonstrated significant treatment efficacy, effectively alleviated anxiety and depression, improved sleep quality, regulated neurotransmitter levels, and suppressed oxidative stress, without increasing adverse side effects.