Perinatal anxiety and depressive symptoms in women with preeclampsia: A cohort study of placental dysfunction and neuroendocrine correlates

doi:10.5498/wjp.117183

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jul 19, 2026; 16(7): 117183
Published online Jul 19, 2026. doi: 10.5498/wjp.117183

Perinatal anxiety and depressive symptoms in women with preeclampsia: A cohort study of placental dysfunction and neuroendocrine correlates

Juan Ma, Yan-Yan Jiang

Juan Ma, Yan-Yan Jiang, Department of Obstetrics, Maternal and Child Health Care Hospital of Shandong Provincial, Affiliated to Qingdao University, Jinan 250014, Shandong Province, China

Author contributions: Ma J designed the study, collected the data, performed the statistical analyses, and drafted the manuscript; Jiang YY supervised the study, guided the methodology, and critically revised the manuscript for important intellectual content; all authors contributed to data interpretation, reviewed the manuscript, approved the final version, and agree to be accountable for all aspects of the work.

AI contribution statement: I have not used ChatGPT, Grammarly, DeepL, or any other AI tools to modify the article. The entire body of the manuscript was not generated by AI. The design of the research results did not use AI tools.

Institutional review board statement: This study has been reviewed and approved by the Institutional Review Board of Maternal and Child Health Care Hospital of Shandong Provincial, No. 2023-039.

Clinical trial registration statement: This study is a cohort study and does not involve any intervention or random allocation. Therefore, clinical trial registration is not applicable.

Informed consent statement: All participants provided informed consent.

Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.

CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.

Data sharing statement: There is no additional data available.

Corresponding author: Yan-Yan Jiang, MD, Department of Obstetrics, Maternal and Child Health Care Hospital of Shandong Provincial, Affiliated to Qingdao University, No. 238 Jingshi East Road, Jinan 250014, Shandong Province, China. yyj18769782656@yeah.net

Received: January 16, 2026
Revised: February 3, 2026
Accepted: March 13, 2026
Published online: July 19, 2026
Processing time: 163 Days and 9.6 Hours

Core Tip

Core Tip: This study highlights the strong association between preeclampsia and elevated perinatal anxiety and depressive symptoms, emphasizing the need for integrated obstetric-psychiatric care. By simultaneously assessing placental dysfunction biomarkers and neuroendocrine stress indicators, the study provides novel evidence for biological pathways linking preeclampsia with mental health vulnerability. Elevated soluble fms-like tyrosine kinase-1/placental growth factor ratios and increased morning cortisol were independently correlated with symptom severity, suggesting potential value in early risk stratification. These findings underscore the importance of routine psychological screening during pregnancy complicated by preeclampsia and support the development of targeted interventions to improve maternal mental health outcomes.