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World J Psychiatry. Jun 19, 2026; 16(6): 119817
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.119817
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.119817
Effect of esketamine-assisted regional block on post-traumatic stress disorder after radical lung cancer surgery: A retrospective clinical study
Yan-Lin Chen, Teng-Chen Feng, Xiao-Min Zhang, Na Liu, Hui-Min Yuan, Jie Yao, Zhen Xing, Department of Anesthesiology, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Rui Bian, Counseling Center, The First Affiliated Hospital of Hebei North University, Zhang
Co-corresponding authors: Jie Yao and Zhen Xing.
Author contributions: Chen YL, Feng TC, and Zhang XM contributed equally to this work; Chen YL and Feng TC designed the study, collected and analyzed the data, and drafted the manuscript; Zhang XM and Liu N participated in data collection and statistical analysis; Yuan HM and Bian R contributed to the interpretation of psychological assessments and critical revision of the manuscript; Yao J and Xing Z conceived the study, supervised the entire research process, and revised the manuscript for important intellectual content, have played important and indispensable roles in the manuscript preparation as the co-corresponding authors; all authors approved the final version of the manuscript and agreed to be accountable for all aspects of the work.
Supported by 2024 Hebei Provincial Medical Science Research Project, No. 20241120.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of The First Affiliated Hospital of Hebei North University (No. K2024056).
Informed consent statement: The requirement for written informed consent was waived by the Ethics Committee of The First Affiliated Hospital of Hebei North University (No. K2024056). Given the retrospective design of the study and the use of existing, anonymized clinical data, the Ethics Committee determined that the research posed no more than minimal risk to participants. All procedures were conducted in accordance with the ethical standards of the institutional research committee and complied with the principles of the Declaration of Helsinki.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest to disclose.
Data sharing statement: The datasets generated and/or analyzed during the current study are not publicly available but are available from the corresponding author (Zhen Xing, 13011560235@163.com) on reasonable request.
Corresponding author: Zhen Xing, Department of Anesthesiology, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. 13011560235@163.com
Received: March 10, 2026
Revised: April 27, 2026
Accepted: May 20, 2026
Published online: June 19, 2026
Processing time: 78 Days and 23.9 Hours
Revised: April 27, 2026
Accepted: May 20, 2026
Published online: June 19, 2026
Processing time: 78 Days and 23.9 Hours
Core Tip
Core Tip: Post-traumatic stress disorder (PTSD) is a real complication impeding recovery and quality of life in patients undergoing radical lung cancer surgery. This study shows that esketamine-assisted regional block can significantly reduce the incidence of postoperative PTSD through inhibition of stress and inflammatory response. These findings suggest that refining perioperative anesthetic techniques, improving postoperative pain treatment and tracking inflammatory indicators are of clinical relevance in early PTSD prevention and will provide novel reference data for comprehensive interventions in lung cancer patients.