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World J Psychiatry. Jun 19, 2026; 16(6): 116435
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.116435
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.116435
Thyroid-stimulating hormone levels and suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder
Han-Xu Deng, Department of Psychopathy and Psychiatry, Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China
Yao-Zhi Liu, School of Psychiatry, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Lin Yang, School of Psychiatry, Medical College of Soochow University, Suzhou 637100, Jiangsu Province, China
Jun-Jun Liu, Department of Psychiatry, Nanjing Meishan Hospital, Nanjing 210039, Jiangsu Province, China
Feng-Nan Jia, Xing-Zhi Xia, Department of Psychiatry, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
Xue-Li Zhao, Department of Sleep Disorders, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
Xiang-Yang Zhang, Hefei Fourth People’s Hospital, Anhui Mental Health Center, Affiliated Psychological Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Xiang-Dong Du, The First Clinical College, Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China
Xiang-Dong Du, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
Co-first authors: Han-Xu Deng and Yao-Zhi Liu.
Co-corresponding authors: Xiang-Yang Zhang and Xiang-Dong Du.
Author contributions: Deng HX and Liu YZ have played important roles in the manuscript preparation as co-first authors; Deng HX, Liu YZ, Yang L, Liu JJ, Jia FN, Zhao XL, and Xia XZ performed the investigation; Deng HX, Liu YZ, Liu JJ, Jia FN, and Xia XZ analyzed and interpreted the data; Deng HX, Liu YZ, and Zhao XL drafted the manuscript; Deng HX, Zhang XY, and Du XD designed the study; Zhang XY and Du XD critically revised the manuscript as co-corresponding authors; all authors have read and approved the final version for publication.
AI contribution statement: We used ChatGPT (GPT-4) solely for language polishing, and Grammarly for basic grammar checking. The authors have manually verified every sentence. All authors take full responsibility for the originality and accuracy of the manuscript.
Supported by Medical Research Key Project of Jiangsu Provincial Health Commission, No. K2023015; Suzhou Major Diseases Clinical Multi-Center Research Project, No. DZXYJ202414; Scientific and Technological Key Program of Suzhou, No. SYW2024008; and Key Discipline of Psychiatry in Suzhou, No. SZXK202521.
Institutional review board statement: The study was approved by the Institutional Review Board of the First Hospital of Shanxi Medical University (No. 2016-Y27) and performed in accordance with the Declaration of Helsinki.
Informed consent statement: All participants provided informed consent.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Data sharing statement: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
Corresponding author: Xiang-Dong Du, Chief Physician, Professor, The First Clinical College, Xuzhou Medical University, No. 209, Tongshan Road, Xuzhou 221004, Jiangsu Province, China. xiangdong-du@163.com
Received: November 12, 2025
Revised: January 6, 2026
Accepted: February 28, 2026
Published online: June 19, 2026
Processing time: 198 Days and 6.9 Hours
Revised: January 6, 2026
Accepted: February 28, 2026
Published online: June 19, 2026
Processing time: 198 Days and 6.9 Hours
Core Tip
Core Tip: This study investigates the relationship between thyroid-stimulating hormone (TSH) levels and suicide attempts in first-episode drug-naïve major depressive disorder patients. The results show a positive independent correlation between TSH levels and suicide attempts, with a significant increase in the correlation when TSH exceeds 5.43 μIU/mL. This finding provides a new biomarker-based perspective for early suicide risk identification in depressed patients.