Zhou XY, Gong XQ, Zhu QF. Letter to the Editor: New neural perspective on suicidal behavior in adolescent depression: Specific amygdala subregional dysconnectivity with visual and socio-cognitive networks. World J Psychiatry 2026; 16(6): 116395 [DOI: 10.5498/wjp.v16.i6.116395]
Corresponding Author of This Article
Quan-Feng Zhu, Associate Chief Pharmacist, Director, Department of Psychiatry, Affiliated Xiaoshan Hospital, Hangzhou Normal University, No. 728 Yuercai North Road, Hangzhou 311200, Zhejiang Province, China. quanfengzhu@126.com
Research Domain of This Article
Neuroimaging
Article-Type of This Article
letter
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Zhou XY, Gong XQ, Zhu QF. Letter to the Editor: New neural perspective on suicidal behavior in adolescent depression: Specific amygdala subregional dysconnectivity with visual and socio-cognitive networks. World J Psychiatry 2026; 16(6): 116395 [DOI: 10.5498/wjp.v16.i6.116395]
World J Psychiatry. Jun 19, 2026; 16(6): 116395 Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.116395
Letter to the Editor: New neural perspective on suicidal behavior in adolescent depression: Specific amygdala subregional dysconnectivity with visual and socio-cognitive networks
Xiao-Yue Zhou, Xiao-Qi Gong, Quan-Feng Zhu
Xiao-Yue Zhou, Xiao-Qi Gong, Quan-Feng Zhu, Department of Psychiatry, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou 311200, Zhejiang Province, China
Co-first authors: Xiao-Yue Zhou and Xiao-Qi Gong.
Author contributions: Zhu QF designed the study and revised the manuscript; Zhou XY and Gong XQ wrote the first draft of the manuscript, and they contributed equally to this manuscript and are co-first authors. All the authors have read and approved the final version to be published.
AI contribution statement: This research utilized artificial intelligence tools for assistance. Before seeking professional language editing services for language polishing, this study utilized AI tools for language translation.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Quan-Feng Zhu, Associate Chief Pharmacist, Director, Department of Psychiatry, Affiliated Xiaoshan Hospital, Hangzhou Normal University, No. 728 Yuercai North Road, Hangzhou 311200, Zhejiang Province, China. quanfengzhu@126.com
Received: November 17, 2025 Revised: January 8, 2026 Accepted: February 10, 2026 Published online: June 19, 2026 Processing time: 195 Days and 3.3 Hours
Core Tip
Core Tip: Adolescents with major depressive disorder and a history of suicide attempts exhibit reduced resting-state functional connectivity between the right lateral amygdala and visual association areas (bilateral occipital lobes), along with abnormal connections involving the parahippocampal gyrus and superior temporal gyrus. These neural patterns are further correlated with lower self-esteem and higher interpersonal stress, offering an integrated neurobiological model linking emotional regulation, self-evaluation, and environmental stress in adolescent suicidality. The findings highlight the potential of amygdala subregion-based analysis in identifying specific neural circuits associated with suicide risk, paving the way for future biomarker development and targeted interventions.
