Yang F, Zhou RJ, Xu W, Li Y, Luan DH, Xu MY. Value of inflammatory markers in predicting psychotic complications of postoperative depression after cerebrovascular intervention. World J Psychiatry 2026; 16(6): 116328 [DOI: 10.5498/wjp.v16.i6.116328]
Corresponding Author of This Article
Ming-Yang Xu, Research Fellow, Department of Neurology, Yangzhou University Affiliated Taixing Hospital, No. 1 Changzheng Road, Taixing 225400, Jiangsu Province, China. xumingyang860624@126.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
research-article
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Yang F, Zhou RJ, Xu W, Li Y, Luan DH, Xu MY. Value of inflammatory markers in predicting psychotic complications of postoperative depression after cerebrovascular intervention. World J Psychiatry 2026; 16(6): 116328 [DOI: 10.5498/wjp.v16.i6.116328]
Feng Yang, Ru-Juan Zhou, Wu Xu, Yan Li, Dong-Heng Luan, Ming-Yang Xu, Department of Neurology, Yangzhou University Affiliated Taixing Hospital, Taixing 225400, Jiangsu Province, China
Author contributions: Yang F was responsible for the conceptualization, methodology, investigation, formal analysis, and writing of the original draft; Zhou RJ contributed to the investigation and data curation; Xu W undertook the validation work for the study; Li Y was in charge of securing the resources required for this research; Luan DH handled the visualization of the study findings; Xu MY oversaw the supervision of the study, acquisition of funding, the review and editing of the manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
AI contribution statement: The authors declare that no AI tools were used in the development or writing of this manuscript and take full responsibility for its integrity, accuracy, and originality.
Supported by China International Medical Foundation “Cerebrovascular Disease Youth Innovation Fund”, No. Z-2016-20-2201.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Yangzhou University Affiliated Taixing Hospital, No. K-W2023015.
Informed consent statement: All study participants and their legal guardians provided written informed consent prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Ming-Yang Xu, Research Fellow, Department of Neurology, Yangzhou University Affiliated Taixing Hospital, No. 1 Changzheng Road, Taixing 225400, Jiangsu Province, China. xumingyang860624@126.com
Received: December 5, 2025 Revised: January 8, 2026 Accepted: March 4, 2026 Published online: June 19, 2026 Processing time: 174 Days and 0.8 Hours
Core Tip
Core Tip: This article of 94 patients undergoing cerebrovascular intervention identified postoperative day 3 serum human chitinase-3-like protein 1 level, postoperative day 7 National Institute of Health Stroke Scale score, and intraoperative complications as independent risk factors for depressive disorder with psychotic complications. Human chitinase-3-like protein 1 demonstrated superior predictive value (area under the curve = 0.892) compared to interleukin-6 and high-sensitivity C-reactive protein, and its levels correlated significantly with Hamilton Depression Rating Scale-17 and Positive and Negative Syndrome Scale positive subscale scores, highlighting its potential as a robust biomarker for early identification of high-risk patients.
