Age-stratified analysis of depression onset patterns and treatment response differences following cerebral infarction

doi:10.5498/wjp.v16.i6.115917

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jun 19, 2026; 16(6): 115917
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.115917

Age-stratified analysis of depression onset patterns and treatment response differences following cerebral infarction

Jun-Jing Li, Zhen-Jie Chen, Wen-Hui Nian, Yi-Liu Liang, Wei-Jin Su

Jun-Jing Li, Yi-Liu Liang, Department of Neurology, Quanzhou First Hospital, Quanzhou 362000, Fujian Province, China

Zhen-Jie Chen, Department of Neurology, Anxi County Hospital, Quanzhou 362400, Fujian Province, China

Wen-Hui Nian, Wei-Jin Su, Department of Emergency Medicine, Jinjiang Municipal Hospital (Shanghai Sixth People’s Hospital Fujian), Quanzhou 362200, Fujian Province, China

Co-first authors: Jun-Jing Li and Zhen-Jie Chen.

Author contributions: Li JJ and Chen ZJ contributed equally as co-first authors and were responsible for study design, data collection, statistical analysis, and manuscript drafting; Nian WH contributed to data collection and manuscript revision; Liang YL supervised the study and critically revised the manuscript; Su WJ participated in patient recruitment and data validation; all authors approved the final manuscript.

AI contribution statement: Only AI language polishing was used. No AI-generated content, study design, data interpretation, or AI-generated images were involved.

Supported by the Joint Innovation Project of Quanzhou Medical College and its Non-Directly Affiliated Hospital, No. XYL2201.

Institutional review board statement: This study was reviewed and approved by the Medical Ethics Committee of Jinjiang Municipal Hospital, Quanzhou, Fujian Province, China (approval No. jjsyyll-2025-039).

Informed consent statement: Given the retrospective nature of the study and the use of anonymized clinical data, the requirement for informed consent was waived by the ethics committee.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request. Due to patient privacy protection and institutional regulations, the raw clinical data cannot be publicly shared.

Corresponding author: Wei-Jin Su, MD, Doctor, Department of Emergency Medicine, Jinjiang Municipal Hospital (Shanghai Sixth People’s Hospital Fujian), No. 16 Luoshan Section, Jinguang Road, Quanzhou 362200, Fujian Province, China. 18750599106@163.com

Received: November 14, 2025
Revised: December 10, 2025
Accepted: January 26, 2026
Published online: June 19, 2026
Processing time: 195 Days and 1.3 Hours

Core Tip

Core Tip: This study reported on post-stroke depression among 300 patients with cerebral injury focusing on both age change variables and differential depression patterns and treatment response. Changes in depression were more pronounced in the younger patients toward the positive and the elderly toward the negative. The elderly patients exhibited the longest depression duration with minimal treatment response. Age, cognitive function, and depression severity alone were effective prognosticators of post-stroke outcomes and additional variables which were more clinically pronounced, were not additive. The study advocates for the formation of age-related post-stroke depression symptomatic treatment and management response protocols to enhance rehabilitation.