BPG is committed to discovery and dissemination of knowledge
Retrospective Cohort Study
Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Psychiatry. Apr 19, 2026; 16(4): 114138
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.114138
Risk characteristics of obesity and atherosclerotic cardiovascular events in patients with schizophrenia: A single-center 10-year retrospective cohort study
Jian-Feng Long, Li-Min Deng, Jian-Dong Zhang, Zhen-Jie Tang, Kang Zhou
Jian-Feng Long, Li-Min Deng, Department of Clinical Nutrition, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
Jian-Dong Zhang, Department of Internal Medicine, Yantai Fushun Hospital, Yantai 264011, Shandong Province, China
Zhen-Jie Tang, Kang Zhou, Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
Author contributions: Long JF and Deng LM contributed to study conception and design, data collection, and manuscript drafting; Zhang JD participated in data acquisition and statistical analysis; Tang ZJ contributed to interpretation of cardiovascular data and critical manuscript revision; Zhou K provided clinical guidance, supervised the overall project, and revised the manuscript for important intellectual content. All authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of The Second Xiangya Second Hospital of Central South University (approval No. 2025-030).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data is available.
Corresponding author: Kang Zhou, MD, Associate Professor, Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. kang.zhou@csu.edu.cn
Received: October 14, 2025
Revised: November 9, 2025
Accepted: December 19, 2025
Published online: April 19, 2026
Processing time: 166 Days and 19 Hours
Core Tip

Core Tip: This 10-year retrospective cohort study investigated the association between obesity and atherosclerotic cardiovascular events in patients with schizophrenia. These findings highlight that obesity significantly increases cardiovascular risk in this vulnerable population, influenced by both antipsychotic treatment and lifestyle factors. Early identification and comprehensive management of metabolic abnormalities are essential to reduce morbidity and mortality. This study underscores the need for integrated psychiatric and medical care strategies to improve the long-term outcomes of patients with schizophrenia.