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World J Psychiatry. Apr 19, 2026; 16(4): 113329
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.113329
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.113329
Maternal thyroid-stimulating hormone and thyroid peroxidase antibody levels: Associations with postpartum depression and impacts on adverse pregnancy outcomes
Jia-Jun Chen, Qiu-Min She, Department of Clinical Laboratory, Shenzhen Bao’an District Songgang People’s Hospital, Shenzhen 518100, Guangdong Province, China
Xue-Jin Chen, Otolaryngology/Head and Neck Surgery Clinic, Shenzhen Children’s Hospital, Shenzhen 518000, Guangdong Province, China
Sheng Ouyang, Department of Obstetrics, Shenzhen Bao’an District Songgang People’s Hos
Author contributions: Chen JJ designed the research and wrote the first manuscript; Chen JJ, Che XJ, and She QM contributed to conceiving the research and analyzing data; Chen JJ and Ouyang S conducted the analysis and provided guidance for the research.
Supported by 2023 Bao’an District Medical and Health Research Project, No. 2023JD214.
Institutional review board statement: This study was approved by the Ethic Committee of Shenzhen Bao’an District Songgang People’s Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Jia-Jun Chen, MD, Department of Clinical Laboratory, Shenzhen Bao’an District Songgang People’s Hospital, No. 2 Shajiang Road, Songgang Subdistrict, Shenzhen 518100, Guangdong Province, China. sp57963@163.com
Received: September 28, 2025
Revised: November 24, 2025
Accepted: December 18, 2025
Published online: April 19, 2026
Processing time: 182 Days and 19.7 Hours
Revised: November 24, 2025
Accepted: December 18, 2025
Published online: April 19, 2026
Processing time: 182 Days and 19.7 Hours
Core Tip
Core Tip: This study included 83 patients with postpartum depression (PPD) and 80 healthy controls. By comparing serum-stimulating hormone and thyroid peroxidase antibody levels and assessing their associations with depressive symptoms, we identified both makers as positively correlated with PPD severity and as independent contributors to adverse pregnancy outcomes. Multiparity and PPD further heightened adverse pregnancy outcomes risk.