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World J Psychiatry. Apr 19, 2026; 16(4): 112755
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.112755
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.112755
Effect of paroxetine on neurological function and psychological state in patients with depression after acute ischemic stroke
Feng-Feng Shen, Dong-Xiao Lin, Hua Li, Department of Neurology, The 900 Hospital of the Joint Logistics Support Force of the People’s Liberation Army of China, Fuzhou 350007, Fujian Province, China
Author contributions: Shen FF and Li H contributed to conception, design, data analysis, manuscript drafting, and manuscript editing; Shen FF and Lin DX contributed to collection, assembly of data, and revised the manuscript; Shen FF contributed to conception, resources, manuscript review, and manuscript editing; and all authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of the 900 Hospital of the Joint Logistics Support Force of the People’s Liberation Army of China (Approval No. 2025-101).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Hua Li, Chief Physician, Department of Neurology, The 900 Hospital of the Joint Logistics Support Force of the People’s Liberation Army of China, No. 90 Hongtang Road, Cangshan District, Fuzhou 350007, Fujian Province, China. 18396546869@163.com
Received: September 12, 2025
Revised: November 12, 2025
Accepted: December 19, 2025
Published online: April 19, 2026
Processing time: 198 Days and 20.4 Hours
Revised: November 12, 2025
Accepted: December 19, 2025
Published online: April 19, 2026
Processing time: 198 Days and 20.4 Hours
Core Tip
Core Tip: We analyzed the clinical effects of paroxetine vs sertraline in treating such patients with post-acute ischemic stroke depression to improve the neurological function and psychological state of patients. Our research results indicated that paroxetine can validly enhance patients’ neurological function and activities of daily living while relieving their negative psychological states, with high curative effects and clinical safety.