Circadian rhythm disruption in bipolar disorder: Mechanisms, clinical significance, and rhythm-oriented interventions

doi:10.5498/wjp.v16.i3.114301

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Mar 19, 2026; 16(3): 114301
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.114301

Circadian rhythm disruption in bipolar disorder: Mechanisms, clinical significance, and rhythm-oriented interventions

Yun Liu, Liu-Ye Zhu, Qi Xiao, Hai-Min Zeng, Yu-Xin Zhan, Ru-Hui Yang, Fang-Zhen Lin, De-Le Liu, Xin-Xing Zeng, Bo-Fan Chen

Yun Liu, Liu-Ye Zhu, Qi Xiao, Hai-Min Zeng, Yu-Xin Zhan, Ru-Hui Yang, Fang-Zhen Lin, De-Le Liu, Xin-Xing Zeng, Bo-Fan Chen, Department of Psychiatry, Jiangxi Mental Hospital, Affiliated Mental Hospital of Nanchang University, Nanchang 330029, Jiangxi Province, China

Liu-Ye Zhu, Hai-Min Zeng, Yu-Xin Zhan, Ru-Hui Yang, Fang-Zhen Lin, De-Le Liu, Xin-Xing Zeng, Bo-Fan Chen, The Second Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China

Qi Xiao, The First Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China

Co-corresponding authors: Yun Liu and Bo-Fan Chen.

Author contributions: Liu Y, Zhu LY, Xiao Q, Zeng HM, and Yang RH drafted the manuscript and performed the major revisions; Zhan YX and Lin FZ prepared and revised the figures; Chen BF, Liu DL, and Zeng XX conducted the literature search and data curation; Liu Y and Chen BF conceived the study, supervised the project, and critically reviewed and edited the manuscript; All authors have discussed the proposed scope and content of the article before drafting and read and approved the final manuscript.

Supported by the National College Students’ Innovative Entrepreneurial Training Plan Program, No. 202410403067; and the Innovation and Entrepreneurship Training Program for College Students in Jiangxi Province, No. S202410403035.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Corresponding author: Yun Liu, PhD, Doctor, Department of Psychiatry, Jiangxi Mental Hospital, Affiliated Mental Hospital of Nanchang University, No. 43 Shangfang Road, Nanchang 330029, Jiangxi Province, China. yunliu02025@163.com

Received: September 16, 2025
Revised: October 22, 2025
Accepted: November 7, 2025
Published online: March 19, 2026
Processing time: 164 Days and 18.5 Hours

Core Tip

Core Tip: Based on the multifaceted role of circadian rhythm disruption in bipolar disorder, this review explored its underlying mechanisms and clinical implications. It highlighted rhythm-oriented interventions as emerging tools for refining diagnosis, improving treatment, and advancing precision psychiatry, ultimately aiming to improve long-term outcomes for patients with mood disorders.