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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Feb 19, 2026; 16(2): 113101
Published online Feb 19, 2026. doi: 10.5498/wjp.v16.i2.113101
Published online Feb 19, 2026. doi: 10.5498/wjp.v16.i2.113101
Clinical investigation of postpartum depression risk factors and screening predictors
Xiao-Wei Yang, Xue-Lian Jiang, Yan-Li Wu, Department of Obstetrics and Gynecology, University-Town Hospital of Chongqing Medical University, Chongqing 401331, China
Co-first authors: Xiao-Wei Yang and Xue-Lian Jiang.
Author contributions: Yang XW and Jiang XL contributed equally to this work as co-first authors; Yang XW was responsible for conceptualization, methodology, data collection, formal analysis, writing - original draft; Jiang XL was responsible for data collection, investigation, literature review, data interpretation, writing, review and editing; Wu YL was responsible for supervision, project administration, conceptualization, validation, writing - review and editing, funding acquisition; all the authors read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of University-Town Hospital of Chongqing Medical University (Approval No. IIT 2025-095).
Informed consent statement: The institutional review board waived the requirement for written informed consent due to the retrospective design and anonymized data.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest related to this study.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Li Wu, MD, Department of Obstetrics and Gynecology, University-Town Hospital of Chongqing Medical University, No. 55 Daxuecheng Middle Road, Shapingba District, Chongqing 401331, China. wuyanli250844754@163.com
Received: September 9, 2025
Revised: October 28, 2025
Accepted: November 24, 2025
Published online: February 19, 2026
Processing time: 142 Days and 22.7 Hours
Revised: October 28, 2025
Accepted: November 24, 2025
Published online: February 19, 2026
Processing time: 142 Days and 22.7 Hours
Core Tip
Core Tip: This study investigated the prevalence, risk factors, and prenatal screening predictors of postpartum depression (PPD) in 376 women at 6 weeks post-partum. The prevalence of PPD according to the Edinburgh Postnatal Depression Scale (EPDS) was 15.7%. Multivariate analysis revealed previous depression or anxiety, marital discord, insufficient social support, pregnancy complications, poor sleep quality, and economic pressure as key independent predictors. An EPDS score ≥ 9 in late pregnancy demonstrated good predictive value. Early identification of high-risk mothers and targeted prenatal interventions may reduce the incidence of PPD and improve maternal-infant health outcomes.