Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Psychiatry. Oct 19, 2026; 16(10): 122042
Published online Oct 19, 2026. doi: 10.5498/wjp.122042
Published online Oct 19, 2026. doi: 10.5498/wjp.122042
Determinants of psychological emotions in lung cancer patients and their correlations with tumor markers and inflammatory cytokines
Peng Wu, School of Medical Laboratory Technology, Xinyang Vocational and Technical College, Xinyang 464000, Henan Province, China
Jun Chen, Department of Pathology, Xinyang 154 Hospital, Xinyang 464000, Henan Province, China
Jie Ding, College Student Mental Health Education Center, Xinyang Vocational and Technical College, Xinyang 464000, Henan Province, China
Feng Shi, Department of Thoracic Surgery, Affiliated Hospital of Xinyang Vocational and Technical College, Xinyang 464000, Henan Province, China
Hua Wu, Department of Medical Oncology, Xinyang Central Hospital, Xinyang 464000, Henan Province, China
Jun Yang, Department of Orthopedics, Affiliated Hospital of Xinyang Vocational and Technical College, Xinyang 464000, Henan Province, China
Co-first authors: Peng Wu and Jun Chen.
Author contributions: Wu P wrote the manuscript, performed data analysis and interpretation; Wu P and Wu H provided the study materials; Wu P and Yang J collected and assembled the data; Chen J, Ding J, and Shi F conceptualized and designed the study; Yang J provided administrative support; Wu P and Chen J contributed equally to this manuscript and are co-first authors. All authors participated in manuscript writing and approved the final manuscript.
AI contribution statement: The authors declare that no AI tools were used in the development or writing of this manuscript and take full responsibility for its integrity, accuracy, and originality.
Supported by Henan Provincial Science and Technology Research Project, No. 242102310491; Henan Provincial Higher Education Key Scientific Research Project Plan, No. 25B320029; and Xinyang Municipal Science and Technology Research Project, No. 20250083.
Institutional review board statement: This study was approved by the Ethic Committee of Affiliated Hospital of Xinyang Vocational and Technical College (Approval No. 2024-01-18).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Corresponding author: Peng Wu, Lecturer, School of Medical Laboratory Technology, Xinyang Vocational and Technical College, No. 48 24th Street, Yangshan New District, Xinyang 464000, Henan Province, China. victorwumed@163.com
Received: April 30, 2026
Revised: June 28, 2026
Accepted: July 28, 2026
Published online: October 19, 2026
Processing time: 163 Days and 1.3 Hours
Revised: June 28, 2026
Accepted: July 28, 2026
Published online: October 19, 2026
Processing time: 163 Days and 1.3 Hours
Core Tip
Core Tip: This study assessed the prevalence of anxiety and depression, alongside associated psychosocial factors, in 128 patients with stage C advanced non-small cell lung cancer undergoing chemoradiotherapy. Additionally, it examined the cross-sectional relationships between these factors and serum tumor markers and pro-inflammatory cytokines. The findings demonstrate a significant correlation between psychological distress and socioeconomic factors; notably, elevated levels of emotional distress are linked to higher biomarker concentrations. This study highlights potential psychoneuroimmunological pathways involved in lung cancer progression and emphasizes the importance of integrating mental health screening into cancer treatment to enhance patients’ physical and mental well-being and improve biological outcomes.