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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jan 19, 2026; 16(1): 113965
Published online Jan 19, 2026. doi: 10.5498/wjp.v16.i1.113965
Published online Jan 19, 2026. doi: 10.5498/wjp.v16.i1.113965
Inflammation and suicide risk in adolescents with self-injury: Expanding the role of mental health nursing
Giuliano Anastasi, Department of Trauma, Azienda Ospedaliera Universitaria Gaetano Martino-Messina, Messina 98121, Sicilia, Italy
Author contributions: Anastasi G conceptualized and wrote the paper.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Giuliano Anastasi, PhD, Adjunct Professor, Department of Trauma, Azienda Ospedaliera Universitaria Gaetano Martino-Messina, No. 1 Via Consolare Valeria, Messina 98121, Sicilia, Italy. giuliano.anastasi@polime.it
Received: September 8, 2025
Revised: October 21, 2025
Accepted: October 29, 2025
Published online: January 19, 2026
Processing time: 114 Days and 11.4 Hours
Revised: October 21, 2025
Accepted: October 29, 2025
Published online: January 19, 2026
Processing time: 114 Days and 11.4 Hours
Core Tip
Core Tip: Inflammatory biomarkers, such as interleukin-10 and interferon-α, have been associated with suicide risk among adolescents with self-injury, offering a biological complement to psychosocial assessment. However, translating these biological profiles into clinical practice will require specialized healthcare workers. Empowering mental health nurses to integrate biomarker monitoring with structured nursing assessment can transform laboratory findings into practical, equitable, and sustainable strategies for adolescent suicide prevention.