Unlocking the silent signals: Motor kinematics as a new frontier in early detection of mild cognitive impairment

Core Tip

Core Tip: This study proposes a paradigm shift in mild cognitive impairment screening, moving from subjective cognitive tests to objective, quantifiable measures of gait and handwriting kinematics. This novel approach uses readily observable behaviors and non-invasive technology (like digital pens) to circumvent barriers of traditional neuropsychological assessments, such as language dependency and cultural bias. By measuring motor kinematics, which capture the real-world effect of cognitive-motor changes, the method offers ecological validity and reflects functional status, distinguishing it from biomarkers focused only on pathology. The integration of gross and fine motor abilities provides a scalable and accessible foundation for early, proactive mild cognitive impairment detection, paving the way for better intervention.