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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jan 19, 2026; 16(1): 112013
Published online Jan 19, 2026. doi: 10.5498/wjp.v16.i1.112013
Published online Jan 19, 2026. doi: 10.5498/wjp.v16.i1.112013
Correlation of ocular surface function with sleep quality, anxiety, and depression in patients with dry eye disease
Yi-Long Lin, Hai-Hua Liu, Kai-Ping Zhang, Department of Ophthalmology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China
Shu-Jin Chen, Department of Ultrasound, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, Fujian Province, China
Qi-Hua Wan, Department of Psychiatry, Longyan Third Hospital, Longyan 364000, Fujian Province, China
Co-first authors: Yi-Long Lin and Hai-Hua Liu.
Author contributions: Lin YL and Liu HH participated in the acquisition, analysis, and interpretation of the data, and drafted the initial manuscript; Chen SJ revised the article critically for important intellectual content; Wan QH provided technical support; Zhang KP designed the study; Lin YL and Liu HH made equal contributions to this work and are co-first authors. All author approval the final manuscript.
Institutional review board statement: The study was approved by the Medical Ethics Committee of Longyan First Affiliated Hospital of Fujian Medical University (Approval No. LTREC2022-K016-01).
Informed consent statement: All study participants, or their legal guardians, provided written informed consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kai-Ping Zhang, Department of Ophthalmology, Longyan First Affiliated Hospital of Fujian Medical University, No. 105 Jiuyi North Road, Xinluo District, Longyan 364000, Fujian Province, China. kaikaiping@163.com
Received: August 8, 2025
Revised: September 13, 2025
Accepted: October 24, 2025
Published online: January 19, 2026
Processing time: 144 Days and 17.8 Hours
Revised: September 13, 2025
Accepted: October 24, 2025
Published online: January 19, 2026
Processing time: 144 Days and 17.8 Hours
Core Tip
Core Tip: This study reveals significant correlations between ocular surface dysfunction and poor sleep quality and anxiety/depression in patients with dry eye disease. Sleep and mood disorders were prevalent among these patients, and factors such as age, sleep quality, and psychological scores independently predicted symptom severity. These findings underscore the importance of integrated, multidisciplinary management for dry eye disease, addressing both ocular and systemic health.