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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jan 19, 2026; 16(1): 110298
Published online Jan 19, 2026. doi: 10.5498/wjp.v16.i1.110298
Published online Jan 19, 2026. doi: 10.5498/wjp.v16.i1.110298
Effects of celecoxib combined with duloxetine on chronic pain, depression, and anxiety in patients with knee osteoarthritis
Xin Liu, Department of Traditional Chinese Medicine Rehabilitation, Honghui Hospital, Xi'an Jiaotong University, Xi’an 710000, Shaanxi Province, China
Qing Fang, Yin-Di Sun, Liang Li, Pain Ward of Orthopedics of Traditional Chinese Medicine, Honghui Hospital, Xi'an Jiaotong University, Xi’an 710000, Shaanxi Province, China
Na Liu, Hao-Hao Liang, Traditional Chinese Medicine Orthopedic Trauma Rehabilitation Ward, Honghui Hospital, Xi'an Jiaotong University, Xi’an 710000, Shaanxi Province, China
Author contributions: Liu X and Fang Q designed the study, collected and analyzed data, and wrote the manuscript; Liu X, Sun YD, Liu N, Li L and Liang HH participated in the study’s conception and data collection; Liu X, Fang Q and Liang HH participated in study design and provided guidance; all authors read and approved the final version.
Institutional review board statement: This study was approved by the Ethic Committee of Honghui Hospital, Xi'an Jiaotong University, approval No. 2025-KY-097-01.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Liang Li, MD, Pain Ward of Orthopedics of Traditional Chinese Medicine, Honghui Hospital, Xi'an Jiaotong University, No. 555 Youyi East Road, Beilin District, Xi’an 710000, Shaanxi Province, China. ll2271005@163.com
Received: August 8, 2025
Revised: September 23, 2025
Accepted: October 30, 2025
Published online: January 19, 2026
Processing time: 144 Days and 18.9 Hours
Revised: September 23, 2025
Accepted: October 30, 2025
Published online: January 19, 2026
Processing time: 144 Days and 18.9 Hours
Core Tip
Core Tip: This study provides an in-depth evaluation of the effects of celecoxib combined with duloxetine on chronic pain, anxiety, and depression in patients with knee osteoarthritis (KOA). The findings indicate that the combined regimen is more effective than monotherapy in reducing pain, improving knee function, and alleviating anxiety and depression. Furthermore, patient age, educational background, and treatment regimen were identified as independent factors influencing emotional outcomes, offering practical guidance for individualized treatment planning. These findings highlight the potential of this therapeutic approach to improve overall clinical outcomes and quality of life in patients with KOA.