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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Sep 19, 2025; 15(9): 108910
Published online Sep 19, 2025. doi: 10.5498/wjp.v15.i9.108910
Published online Sep 19, 2025. doi: 10.5498/wjp.v15.i9.108910
Peripheral blood biomarkers and mild behavioral impairment in mild cognitive impairment: Clinical correlations and mechanistic insights
Wen-Yong Qiao, Qing-Mei Guo, School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
Xu-Hao Li, School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
Co-corresponding authors: Qing-Mei Guo and Xu-Hao Li.
Author contributions: Qiao WY wrote the manuscript and revised the manuscript; Guo QM and Li XH designed the overall concept and outline of the manuscript, contributed equally to this article, and are the co-corresponding authors of this manuscript; All authors contributed to this paper and have approved the final version of the manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qing-Mei Guo, School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, No. 4655 University Road, Jinan 250355, Shan
Received: April 27, 2025
Revised: June 22, 2025
Accepted: July 25, 2025
Published online: September 19, 2025
Processing time: 123 Days and 7.4 Hours
Revised: June 22, 2025
Accepted: July 25, 2025
Published online: September 19, 2025
Processing time: 123 Days and 7.4 Hours
Core Tip
Core Tip: Both mild cognitive impairment and healthy older adults have a higher prevalence of mild behavioral impairment, with changes in impulse control behavior being the most common. Mild behavioral impairment is not only an independent risk factor for cognitive decline but is also associated with peripheral biomarkers associated with Alzheimer’s disease.