Polyphenols: A top-down approach to nutrition and depression

doi:10.5498/wjp.v15.i9.107828

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Sep 19, 2025 (publication date) through Aug 30, 2025

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World Journal of Psychiatry

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2220-3206

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World J Psychiatry. Sep 19, 2025; 15(9): 107828
Published online Sep 19, 2025. doi: 10.5498/wjp.v15.i9.107828

Polyphenols: A top-down approach to nutrition and depression

Nataša R Mijailović, Maja Milojević-Rakić, Katarina Mihajlović

Nataša R Mijailović, Katarina Mihajlović, Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia

Maja Milojević-Rakić, Faculty of Physical Chemistry, University of Belgrade, Belgrade 11000, Serbia

Author contributions: Mijailović NR conceptualized the manuscript; Mijailović NR and Mihajlović K structured the manuscript; Mijailović NR, Milojević-Rakić M, and Mihajlović K wrote the manuscript and provided feedback; All authors gave their consent to the submitted version of the manuscript.

Supported by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia, No. 451-03-137/2025-03/200111 and No. 451-03-137/2025-03/200146.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Nataša R Mijailović, PhD, Assistant Professor, Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69 Street, Kragujevac 34000, Serbia. nacakg@gmail.com

Received: April 1, 2025
Revised: April 28, 2025
Accepted: July 8, 2025
Published online: September 19, 2025
Processing time: 150 Days and 14 Hours

Core Tip

Core Tip: Dietary polyphenols are promising nutraceuticals for treating brain disorders. They have been elucidated as a non-invasive, natural, and cost-effective approach to alleviating depressive symptoms. Polyphenols may target a variety of pathophysiological pathways to exert neuroprotective effects. These effects may be accomplished by modulating inflammatory pathways and the immune system, trophic factors, neurotransmitters, gut microbiota, and oxidative stress. Understanding these mechanisms may lead to more tailored therapeutic strategies and novel antidepressant therapies. Clinical studies regarding polyphenols are crucial to support the beneficial effects of these compounds as demonstrated in preclinical research.