Gao B, Gao YF, Chu MT, Yuan KF. Depressive state on cardiac remodeling and left ventricular function in chronic heart failure: A retrospective study. World J Psychiatry 2025; 15(9): 106906 [DOI: 10.5498/wjp.v15.i9.106906]
Corresponding Author of This Article
Ke-Fang Yuan, Department of Cardiovascular Surgery, Hebei Petro China Central Hospital, No. 51 Xinkai Road, Langfang 065000, Hebei Province, China. yuankf198301@163.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Sep 19, 2025; 15(9): 106906 Published online Sep 19, 2025. doi: 10.5498/wjp.v15.i9.106906
Depressive state on cardiac remodeling and left ventricular function in chronic heart failure: A retrospective study
Bo Gao, Yun-Fan Gao, Meng-Ting Chu, Ke-Fang Yuan
Bo Gao, Department of Cardiology, Suizhou Central Hospital, Affiliated Hospital of Hubei University of Medicine, Suizhou 441300, Hubei Province, China
Yun-Fan Gao, Department of Emergency, Suizhou Central Hospital, Affiliated Hospital of Hubei University of Medicine, Suizhou 441300, Hubei Province, China
Meng-Ting Chu, Department of Pain and Rehabilitation, Suizhou Central Hospital, Affiliated Hospital of Hubei University of Medicine, Suizhou 441300, Hubei Province, China
Ke-Fang Yuan, Department of Cardiovascular Surgery, Hebei Petro China Central Hospital, Langfang 065000, Hebei Province, China
Co-first authors: Bo Gao and Yun-Fan Gao.
Author contributions: Gao B, Gao YF, Chu MT conceived and designed the study, performed the statistical analysis, and wrote the manuscript; Yuan KF collected and processed the data, conducted literature research, and critically revised the manuscript for important intellectual content. Both authors reviewed and approved the final version of the manuscript. Gao B and Gao YF contributed equally to this work as co-first authors.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Suizhou Central Hospital, Hubei Province, China (Approval No. KY-2025-002-01). The study was conducted in accordance with the principles outlined in the Declaration of Helsinki.
Informed consent statement: Informed consent was waived by the Medical Ethics Committee of Suizhou Central Hospital (KY-2025-002-01) due to the retrospective design and use of de-identified data.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this study.
Data sharing statement: The data supporting the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ke-Fang Yuan, Department of Cardiovascular Surgery, Hebei Petro China Central Hospital, No. 51 Xinkai Road, Langfang 065000, Hebei Province, China. yuankf198301@163.com
Received: April 15, 2025 Revised: June 2, 2025 Accepted: July 9, 2025 Published online: September 19, 2025 Processing time: 133 Days and 1.4 Hours
Core Tip
Core Tip: This study highlights a significant link between depression and cardiac remodeling in chronic heart failure (CHF) patients. Depression was associated with lower left ventricular ejection fraction, larger end-diastolic diameter, increased myocardial fibrosis, and elevated inflammatory and neuroendocrine markers. These findings suggest that depressive states exacerbate structural and functional cardiac abnormalities through inflammatory activation, neuroendocrine dysregulation, and enhanced oxidative stress. The results underscore the importance of psychological assessment and targeted management of depression in CHF patients. Addressing depression may mitigate its detrimental cardiovascular effects, offering a potential avenue to improve clinical outcomes and quality of life for patients with heart failure.
