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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Jul 19, 2025; 15(7): 107598
Published online Jul 19, 2025. doi: 10.5498/wjp.v15.i7.107598
Published online Jul 19, 2025. doi: 10.5498/wjp.v15.i7.107598
Diagnosis and etiology of poststroke depression: A review
Meng-Chan Lin, Department of Psychiatry, National Cheng Kung University Hospital, Tainan 70403, Taiwan
Si-Sheng Huang, Division of Geriatric Psychiatry, Department of Psychiatry, Changhua Christian Hospital, Changhua 500, Taiwan
Si-Sheng Huang, Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan
Author contributions: Lin MC and Huang SS designed the study and interpreted the data; Lin MC drafted the article; Huang SS made critical revisions related to important intellectual content of the manuscript; Lin MC and Huang SS approved the final version of the article to be published.
Conflict-of-interest statement: The authors have no conflicts of interest relevant to this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Si-Sheng Huang, MD, Division of Geriatric Psychiatry, Department of Psychiatry, Changhua Christian Hospital, No. 135 Nanhsiao Street, Changhua 500, Taiwan. 97278@cch.org.tw
Received: March 27, 2025
Revised: April 20, 2025
Accepted: June 3, 2025
Published online: July 19, 2025
Processing time: 105 Days and 20.6 Hours
Revised: April 20, 2025
Accepted: June 3, 2025
Published online: July 19, 2025
Processing time: 105 Days and 20.6 Hours
Core Tip
Core Tip: Patients who have suffered stroke exhibit a higher rate of depression than do other patients with similar levels of disability. This phenomenon suggests an association between stroke and poststroke depression (PSD). Clinical challenges are encountered in diagnosing PSD, as the cognitive and physical impairments resulting from stroke can interfere with the assessment of depressive symptoms. PSD is currently believed to be the result of physiological and psychosocial factors. It is speculated that the mechanisms underlying the depressive symptoms that arise after a stroke are primarily physiological in the early stages and are later related to psychosocial factors.