Yuan L, Zhang XM, Liu N, Shi JQ, Sun XJ, Li GL, Teng JL. Permissive hypercapnia combined with goal-directed fluid therapy improve postoperative mental health in elderly patients undergoing laparoscopic surgery. World J Psychiatry 2025; 15(7): 106023 [DOI: 10.5498/wjp.v15.i7.106023]
Corresponding Author of This Article
Jin-Liang Teng, MD, Chief Physician, Department of Anesthesiology, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Qiaoxi District, Zhangjiakou 075000, Hebei Province, China. tengjinliang@126.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Jul 19, 2025; 15(7): 106023 Published online Jul 19, 2025. doi: 10.5498/wjp.v15.i7.106023
Permissive hypercapnia combined with goal-directed fluid therapy improve postoperative mental health in elderly patients undergoing laparoscopic surgery
Li Yuan, Xiao-Min Zhang, Na Liu, Jun-Qi Shi, Xiao-Jie Sun, Guo-Li Li, Jin-Liang Teng
Li Yuan, Xiao-Min Zhang, Na Liu, Jun-Qi Shi, Guo-Li Li, Jin-Liang Teng, Department of Anesthesiology, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Xiao-Jie Sun, Intensive Care Unit, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Author contributions: Yuan L and Zhang XM contributed equally to this work and were responsible for data collection, statistical analysis, and manuscript drafting; Liu N and Shi JQ participated in patient recruitment, perioperative management, and follow-up; Sun XJ contributed to critical care data extraction and interpretation; Li GL assisted in study design and literature review; Teng JL conceived and supervised the study, revised the manuscript, and is the corresponding author and all authors read and approved the final manuscript.
Supported by the 2024 Hebei Medical Science Research Project, No. 20241638; and Key Research and Development Program of Zhangjiakou City, No. 2311041D.
Institutional review board statement: This study was approved by the Medical Ethics Committee of The First Affiliated Hospital of Hebei North University, approval No. K2024141.
Informed consent statement: Informed consent was waived by the Medical Ethics Committee of The First Affiliated Hospital of Hebei North University due to the retrospective nature of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Liang Teng, MD, Chief Physician, Department of Anesthesiology, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Qiaoxi District, Zhangjiakou 075000, Hebei Province, China. tengjinliang@126.com
Received: March 7, 2025 Revised: April 19, 2025 Accepted: June 10, 2025 Published online: July 19, 2025 Processing time: 124 Days and 20.6 Hours
Core Tip
Core Tip: This study highlights the benefits of permissive hypercapnia (PH) combined with goal-directed fluid therapy (GDFT) in elderly patients undergoing laparoscopic surgery. The PH + GDFT strategy is demonstrated to significantly accelerate postoperative recovery, reduce complications, and alleviate anxiety and depression. Additionally, it is observed to reduce levels of inflammatory markers, enhance sleep quality, and improve overall patient satisfaction. Multivariate analysis confirms PH + GDFT as an independent protective factor against postoperative psychological distress. These findings advocate for the integration of PH and GDFT into perioperative management to optimize both physical and psychological outcomes, particularly for elderly patients. This study offers clinical evidence supporting the refinement of anesthesia and fluid management strategies in minimally invasive surgery.
