Case Control Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. May 19, 2025; 15(5): 103256
Published online May 19, 2025. doi: 10.5498/wjp.v15.i5.103256
Correlation between mild behavioral impairment and peripheral blood biomarkers in patients with mild cognitive impairment
Wei Liang, Lan Wang, Mei Song, Hao Geng, Xin-Yang Jing, Wei Li, Ya-Xin Huo, An-Qi Huang, Xue-Yi Wang, Cui-Xia An
Wei Liang, Lan Wang, Mei Song, Hao Geng, Xin-Yang Jing, Wei Li, Ya-Xin Huo, An-Qi Huang, Xue-Yi Wang, Cui-Xia An, Mental Health Center, The First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei Province, China
Wei Liang, Xi’an Mental Health Center, Xi’an 710061, Shaanxi Province, China
Lan Wang, Hebei Key Laboratory of Forensic Medicine, Shijiazhuang 050017, Hebei Province, China
Co-first authors: Wei Liang and Lan Wang.
Author contributions: Liang W contributed to investigation, formal analysis, data curation, writing original draft; Wang L contributed to investigation, writing original draft; Song M contributed to investigation, funding acquisition; Geng H, Jing XY, Li W, Huo YX, Huang AQ contributed to investigation; Wang XY contributed to conceptualization; An CX contributed to conceptualization, funding acquisition, writing, review and editing; All authors read and approved the final manuscript.
Supported by the Government Funded Clinical Medicine Excellent Talents Training Project of Hebei Province, No. ZF2024136; National Science Foundation of Hebei Province, No. H2022206544; and Science and Technology Program of Hebei Province, No. SG2021189.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of The First Hospital of Hebei Medical University (No. 20210902).
Informed consent statement: Each participant provided signed informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cui-Xia An, MD, Professor, Mental Health Center, The First Hospital of Hebei Medical University, No. 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China. acxsunny@hebmu.edu.cn
Received: November 14, 2024
Revised: February 28, 2025
Accepted: April 3, 2025
Published online: May 19, 2025
Processing time: 168 Days and 4.8 Hours
Core Tip

Core Tip: Both mild cognitive impairment and healthy older adults have shown a higher prevalence of mild behavioral impairment (MBI), with changes in impulse control behavior being the most common. MBI not only stands as an independent risk factor for cognitive decline but is also associated with Alzheimer’s disease-related peripheral biomarkers.