Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Feb 19, 2025; 15(2): 102598
Published online Feb 19, 2025. doi: 10.5498/wjp.v15.i2.102598
Neutrophil gelatinase-associated lipocalin as a biomarker for neuropsychiatric complications in acute ischemic stroke
Uchenna E Okpete, Haewon Byeon
Uchenna E Okpete, Haewon Byeon, Department of Digital Anti-aging Healthcare (BK21), Inje University, Gimhae 50834, South Korea
Author contributions: Okpete UE and Byeon H contributed to this paper and assisted with writing the article; Byeon H designed the study; Okpete UE involved in data interpretation and developed methodology; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the Basic Science Research Program through the National Research Foundation of Korea Funded by the Ministry of Education, No. RS-2023-00237287; and Regional Innovation Strategy Through the National Research Foundation of Korea Funded by the Ministry of Education, No. 2021RIS-003.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Haewon Byeon, Associate Professor, PhD, Department of Digital Anti-aging Healthcare (BK21), Inje University, No. 197 Injero, Gimhae 50834, South Korea. bhwpuma@naver.com
Received: October 23, 2024
Revised: December 17, 2024
Accepted: December 23, 2024
Published online: February 19, 2025
Processing time: 83 Days and 7 Hours
Core Tip

Core Tip: This study investigates neutrophil gelatinase-associated lipocalin (NGAL) as a potential biomarker for neuropsychiatric complications in patients with acute ischemic stroke. Gu et al demonstrate that elevated NGAL levels at admission are associated with a higher risk of cognitive impairment, anxiety, and depression. These findings are significant because such conditions, often overlooked, substantially impact post-stroke recovery and quality of life. This research broadens the understanding of NGAL’s functions beyond its established role as a biomarker for early kidney injury, emphasizing its relevance in neuroinflammation and neuropsychiatric processes.