Lithium and valproic acid in bipolar disorder: Beyond mood stabilization, the overlooked role of sleep

doi:10.5498/wjp.v15.i12.113893

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 15, Issue 12

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (326)

All Articles published online

The chart showing PDF series, HTML series.

Item

Count

PDF

HTML

Sum=98

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

135

Sum=226

Publishing Process of This Article

Item

Count

Browse

Download

Sum=24

Dec 19, 2025 (publication date) through Dec 9, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Psychiatry

ISSN

2220-3206

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Psychiatry. Dec 19, 2025; 15(12): 113893
Published online Dec 19, 2025. doi: 10.5498/wjp.v15.i12.113893

Lithium and valproic acid in bipolar disorder: Beyond mood stabilization, the overlooked role of sleep

Esra Kabadayi Sahin

Esra Kabadayi Sahin, Department of Psychiatry, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara 06800, Türkiye

Author contributions: Kabadayi Sahin E contributed to the conceptualization, writing, reviewing, and editing of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Esra Kabadayi Sahin, MD, Associate Professor, Department of Psychiatry, Ankara Yildirim Beyazit University Faculty of Medicine, Universiteler Mahallesi, Cankaya, Ankara 06800, Türkiye. ekabadayi06@gmail.com

Received: September 5, 2025
Revised: September 17, 2025
Accepted: October 11, 2025
Published online: December 19, 2025
Processing time: 83 Days and 1.2 Hours

Core Tip

Core Tip: This letter emphasizes the importance of evaluating sleep as a central physiological parameter in bipolar disorder. While the original study demonstrated lithium's advantage over valproic acid in sleep quality. It is highlighted that reliance solely on self-reported scales is a limitation. Wearable technologies and actigraphy offer objective, scalable alternatives to polysomnography. Future studies should integrate serum drug-level monitoring and adjunctive antipsychotic data into longitudinal designs to clarify how mood stabilizers influence sleep and to advance personalized treatment strategies in bipolar disorder.