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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Dec 19, 2025; 15(12): 113433
Published online Dec 19, 2025. doi: 10.5498/wjp.v15.i12.113433
Published online Dec 19, 2025. doi: 10.5498/wjp.v15.i12.113433
Selecting an appropriate stress model of depression in rodents
Xiao-Xue Lu, Xu-Hao Li, School of Acupuncture-Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
Hao Tang, School of Tuina, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan 250014, Shandong Province, China
Author contributions: Lu XX and Li XH contributed to writing of original draft; Li XH and Tang H contributed to review and editing; Tang H and Li XH contributed to visualization; Li XH did supervision and project administration; Lu XX acquired the funding. All authors have read and agreed to the published version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xu-Hao Li, Lecturer, Post Doctoral Researcher, Postdoc, School of Acupuncture-Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, No. 4655 University Road, Changqing District, Jinan 250355, Shandong Province, China.
Received: August 26, 2025
Revised: September 16, 2025
Accepted: October 27, 2025
Published online: December 19, 2025
Processing time: 94 Days and 4.3 Hours
Revised: September 16, 2025
Accepted: October 27, 2025
Published online: December 19, 2025
Processing time: 94 Days and 4.3 Hours
Core Tip
Core Tip: Although there has been extensive research on depression through animal models, it is undeniable that it is challenging to directly and comprehensively find stress-related depression animal models in the literature. This is because existing studies mostly lump together stress, medication, genetic, and surgical factors in summarizing depression models without clear differentiation. Based on this, we have conducted the first relatively comprehensive summary of depression models caused by stress.