Zhu ZJ, Liu KL, Qu HR. Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease. World J Psychiatry 2025; 15(12): 110916 [PMID: 41357912 DOI: 10.5498/wjp.v15.i12.110916]
Corresponding Author of This Article
Huan-Ru Qu, MD, Department of Rheumatology and Immunology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725 Wanping South Road, Xuhui District, Shanghai 200032, China. huan19215336566@163.com
Research Domain of This Article
Psychiatry
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Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 19, 2025 (publication date) through Dec 9, 2025
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Publication Name
World Journal of Psychiatry
ISSN
2220-3206
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Zhu ZJ, Liu KL, Qu HR. Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease. World J Psychiatry 2025; 15(12): 110916 [PMID: 41357912 DOI: 10.5498/wjp.v15.i12.110916]
World J Psychiatry. Dec 19, 2025; 15(12): 110916 Published online Dec 19, 2025. doi: 10.5498/wjp.v15.i12.110916
Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease
Zhu-Jing Zhu, Kai-Lin Liu, Huan-Ru Qu
Zhu-Jing Zhu, Kai-Lin Liu, Huan-Ru Qu, Department of Rheumatology and Immunology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Author contributions: Zhu ZJ, Liu KL, and Qu HR designed the research study; Zhu ZJ and Qu HR performed the research; Zhu ZJ and Qu HR contributed new reagents and analytic tools; Zhu ZJ, Liu KL, and Qu HR analyzed the data and wrote the manuscript. All the authors have read and approved the final manuscript.
Supported by Construction of a High-level Research-oriented Traditional Chinese Medicine Hospital, No. YC-2023-0901.
Institutional review board statement: This research has been reviewed and approved by the Medical Ethics Committee of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine.
Informed consent statement: The informed consent forms signed by the patients were obtained in this study.
Conflict-of-interest statement: The authors of this study declare that there is no conflict of interest.
Data sharing statement: No available data.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Huan-Ru Qu, MD, Department of Rheumatology and Immunology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725 Wanping South Road, Xuhui District, Shanghai 200032, China. huan19215336566@163.com
Received: July 29, 2025 Revised: August 27, 2025 Accepted: October 10, 2025 Published online: December 19, 2025 Processing time: 121 Days and 1.6 Hours
Core Tip
Core Tip: This retrospective study investigates the association between anxiety, depression, dyspnea severity, and pulmonary function in patients with Connective tissue disease-associated interstitial lung disease (CTD-ILD). Results revealed that higher anxiety (generalized anxiety disorder-7) and depression (patient health questionnaire-9) scores were significantly correlated with worse pulmonary function (forced vital capacity, diffusing capacity of the lungs for carbon monoxide), more severe dyspnea (modified medical research council score), and elevated systemic inflammation (C-reactive protein, erythrocyte sedimentation rate). Moreover, psychological distress emerged as an independent predictor of pulmonary function decline. These findings underscore the importance of routine psychological assessment and timely intervention in CTD-ILD management to prevent deterioration and improve prognosis.
