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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Dec 19, 2025; 15(12): 109906
Published online Dec 19, 2025. doi: 10.5498/wjp.v15.i12.109906
Published online Dec 19, 2025. doi: 10.5498/wjp.v15.i12.109906
Maternal factors contributing to variability in gut microbiota and gastrointestinal function in autism spectrum disorders
Xiao-Xi Wang, China Academy of Chinese Medical Sciences, Institute of Acupuncture and Moxibustion, Beijing 100000, China
Author contributions: Wang XX designed the overall concept and outline of the manuscript, reviewed the literature, and wrote the manuscript.
Supported by the National Natural Science Foundation of China, No. 82305035; China Academy of Chinese Medical Sciences, Special Project for Cultivating Outstanding Young Scientific and Technological Talents, No. 2217-YQ-029; and Institute of Acupuncture, China Academy of Chinese Medical Sciences, Special Project for Innovative Talents, No. ZZ-YC2023002.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Xi Wang, PhD, China Academy of Chinese Medical Sciences, Institute of Acupuncture and Moxibustion, No. 16 South Street, Dongzhimen Nei, Beijing 100000, China. wxxcacms@163.com
Received: May 26, 2025
Revised: July 9, 2025
Accepted: October 27, 2025
Published online: December 19, 2025
Processing time: 186 Days and 18.4 Hours
Revised: July 9, 2025
Accepted: October 27, 2025
Published online: December 19, 2025
Processing time: 186 Days and 18.4 Hours
Core Tip
Core Tip: The pathogenic factors of autism are closely related to maternal health during pregnancy. Adverse factors during pregnancy, such as infections and psychological stress, can affect the development of the offspring’s central and enteric nervous systems, leading to core symptoms of autism and gastrointestinal problems. Therefore, maternal health during pregnancy must be monitored to reduce the incidence of autism.