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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Nov 19, 2025; 15(11): 112431
Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.112431
Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.112431
Computerized cognitive behavioral therapy with sertraline in schizophrenia with depressive episodes: A 12-week randomized controlled trial
Ren-Chun Huang, Nan Lin, Xiao-Dan Li, Department of Psychiatry, Fuzhou Neuropsychiatric Hospital Affiliated to Fujian Medical University, Fuzhou 350004, Fujian Province, China
Nicha Wareesawetsuwan, Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02108, United States
Author contributions: Huang RC and Li XD designed the study; Huang RC, Li XD and Lin N collected the data; Wareesawetsuwan N analyzed the data and critically revised the manuscript; Huang RC drafted the manuscript; Li XD and Wareesawetsuwan N critically revised the manuscript.
Supported by Fuzhou Science and Technology Plan Project, No. 2023-S-028.
Institutional review board statement: This study has been approved by the Ethics Committee of The Second General Hospital of Fuzhou Neuropsychiatric Prevention and Treatment Hospital (2023 Ethics Review No.16).
Clinical trial registration statement: This study is registered at Chinese Clinical Trials Registry. The registration identification number is ChiCTR2500098302.
Informed consent statement: All participants and guardians signed informed consent forms before the start of the trial.
Conflict-of-interest statement: The authors disclose no conflicts.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Dan Li, MD, PhD, Department of Psychiatry, Fuzhou Neu
Received: July 28, 2025
Revised: August 9, 2025
Accepted: September 4, 2025
Published online: November 19, 2025
Processing time: 100 Days and 13.3 Hours
Revised: August 9, 2025
Accepted: September 4, 2025
Published online: November 19, 2025
Processing time: 100 Days and 13.3 Hours
Core Tip
Core Tip: This randomized controlled trial demonstrates that combining computerized cognitive behavioral therapy (CCBT) with sertraline is more effective than sertraline alone in improving depressive symptoms, cognitive function, and quality of life in patients with schizophrenia and depressive episodes. Notably, CCBT significantly enhanced processing speed and social cognition. These findings support CCBT as a scalable, accessible, and effective adjunct to pharmacotherapy in this challenging population.