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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Nov 19, 2025; 15(11): 110018
Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.110018
Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.110018
Investigation of depressive symptoms after thyroid cancer surgery: Logistic regression analysis and adjustment strategy
Qi Xie, Yun-Chao Xin, Li-Hang Yang, Chuan Liu, Ze-Dong Tian, Xiao-Ling Shang, Department of Otorhinolaryngology, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Author contributions: Xie Q designed the study; Yang LH, Liu C, and Tian ZD contributed to the analysis of the manuscript; Shang XL guided the research direction; and Xie Q and Xin YC were involved in the data collection and writing of this article. All the authors have read and approved the final version of the manuscript.
Supported by Clinical Study on Perioperative Issues Related to Thyroidectomy, No. 20241209; Risk Factors and Coping Strategies for Postoperative Cough in Thyroid Nodules, No. 2322152D; and Research on Individualized Surgical Treatment Strategies for Thyroid Tumors Jicai Pre-recovery, No. [2020] 397.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the First Affiliated Hospital of Hebei North University.
Informed consent statement: All study participants and their legal guardians provided written informed consent before recruitment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Ling Shang, Chief Physician, Department of Otorhinolaryngology, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. xieqi811@126.com
Received: July 8, 2025
Revised: August 9, 2025
Accepted: August 25, 2025
Published online: November 19, 2025
Processing time: 117 Days and 22.8 Hours
Revised: August 9, 2025
Accepted: August 25, 2025
Published online: November 19, 2025
Processing time: 117 Days and 22.8 Hours
Core Tip
Core Tip: This study revealed a 57.4% prevalence of depression in post-thyroidectomy patients, with key risk factors including low family income (< 3000 yuan/month, OR = 5.26), 131I therapy (OR = 5.70), and avoidant coping style (OR = 4.77). Strong social support had a significant protective effect (OR = 0.22). These findings highlight the critical need for routine depression screening and targeted psychosocial interventions, particularly in patients undergoing 131I treatment or exhibiting maladaptive coping behaviors. The identification of modifiable risk factors (coping styles) and protective factors (social support) provides actionable targets for improving mental health outcomes in thyroid cancer survivors.