Khan MM. Erythrocyte membrane nervonic acid in drug-naive first-episode psychosis and chronic medicated schizophrenia: Implication for impaired myelination and prognosis. World J Psychiatry 2025; 15(11): 109162 [DOI: 10.5498/wjp.v15.i11.109162]
Corresponding Author of This Article
Mohammad M Khan, PhD, Professor, Laboratory of Translational Neurology and Molecular Psychiatry, Department of Biotechnology, Era’s Lucknow Medical College and Hospital, and Faculty of Science, Era University, Sarfarazganj, Hardoi Road, Lucknow 226003, India. mmkhan0@gmail.com
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Psychiatry
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Observational Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 19, 2025 (publication date) through Nov 3, 2025
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Publication Name
World Journal of Psychiatry
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2220-3206
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Khan MM. Erythrocyte membrane nervonic acid in drug-naive first-episode psychosis and chronic medicated schizophrenia: Implication for impaired myelination and prognosis. World J Psychiatry 2025; 15(11): 109162 [DOI: 10.5498/wjp.v15.i11.109162]
World J Psychiatry. Nov 19, 2025; 15(11): 109162 Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.109162
Erythrocyte membrane nervonic acid in drug-naive first-episode psychosis and chronic medicated schizophrenia: Implication for impaired myelination and prognosis
Mohammad M Khan
Mohammad M Khan, Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, Augusta 30912, GA, United States
Mohammad M Khan, Laboratory of Translational Neurology and Molecular Psychiatry, Department of Biotechnology, Era’s Lucknow Medical College and Hospital, and Faculty of Science, Era University, Lucknow 226003, India
Author contributions: Khan MM conceived the idea, designed the experiment and wrote the manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Medical College of Georgia, Augusta, GA, and Dwight David Eisenhower Army Medical Center.
Informed consent statement: A signed consent was taken from all the patients and CNT subjects at the time of samples collection.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: All the data is available with the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammad M Khan, PhD, Professor, Laboratory of Translational Neurology and Molecular Psychiatry, Department of Biotechnology, Era’s Lucknow Medical College and Hospital, and Faculty of Science, Era University, Sarfarazganj, Hardoi Road, Lucknow 226003, India. mmkhan0@gmail.com
Received: May 9, 2025 Revised: June 4, 2025 Accepted: September 12, 2025 Published online: November 19, 2025 Processing time: 186 Days and 19.5 Hours
Core Tip
Core Tip: Nervonic acid (NA, C24: 1, w9) is a monounsaturated fatty acid that plays a crucial role in myelination and motor function. It also regulates cognitive and metabolic functions, suggesting that impaired NA metabolism may contribute to the pathophysiology of schizophrenia. Although several studies have measured erythrocyte membrane NA in first-episode psychosis, findings are conflicting, and the fate of NA in patients with chronic schizophrenia or under long-term antipsychotic treatment schedule remains unknown. This study was designed to analyze erythrocyte NA composition and its association with psychopathology and metabolic comorbidities in drug-naive patients with first-episode psychosis and antipsychotic-treated patients with chronic schizophrenia.
