Guo L, He LX, Wan PQ, Zhen XM, Xiao F, Wu WB, Su MH, Gao BH, Liu ZH. Meta-analysis of factors associated with the incidence of comorbid depression and anxiety in patients with chronic hepatitis B. World J Psychiatry 2025; 15(11): 106164 [DOI: 10.5498/wjp.v15.i11.106164]
Corresponding Author of This Article
Zhi-Hong Liu, Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. liuzh308@163.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 19, 2025 (publication date) through Nov 3, 2025
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Psychiatry
ISSN
2220-3206
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Guo L, He LX, Wan PQ, Zhen XM, Xiao F, Wu WB, Su MH, Gao BH, Liu ZH. Meta-analysis of factors associated with the incidence of comorbid depression and anxiety in patients with chronic hepatitis B. World J Psychiatry 2025; 15(11): 106164 [DOI: 10.5498/wjp.v15.i11.106164]
World J Psychiatry. Nov 19, 2025; 15(11): 106164 Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.106164
Meta-analysis of factors associated with the incidence of comorbid depression and anxiety in patients with chronic hepatitis B
Li Guo, Li-Xia He, Pei-Qi Wan, Xiu-Mei Zhen, Fang Xiao, Wen-Bin Wu, Ming-Hua Su, Bi-Hua Gao, Zhi-Hong Liu
Li Guo, Wen-Bin Wu, Bi-Hua Gao, Department of Infectious Diseases, Beihai People's Hospital, Beihai 536000, Guangxi Zhuang Autonomous Region, China
Li-Xia He, Pei-Qi Wan, Xiu-Mei Zhen, Fang Xiao, Ming-Hua Su, Zhi-Hong Liu, Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Co-corresponding authors: Bi-Hua Gao and Zhi-Hong Liu.
Author contributions: Guo L designed this study; Guo L, He LX, Wan PQ, Zhen XM, Xiao F, Wu WB, Su MH, Gao BH and Liu ZH analyzed the data; Guo L wrote manuscript; all authors read and approved the final manuscript; Gao BH and Liu ZH contribute equally to this study as co-corresponding authors.
Supported by Beihai City Science and Technology Program Projects, No. Beikehe 2023158020.
Conflict-of-interest statement: No additional data are available.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Hong Liu, Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. liuzh308@163.com
Received: May 28, 2025 Revised: July 14, 2025 Accepted: August 26, 2025 Published online: November 19, 2025 Processing time: 158 Days and 20.8 Hours
Core Tip
Core Tip: Patients with chronic hepatitis B may experience a significant burden of mental-health issues, with 30.1% experiencing depression, 40.2% anxiety, and 33.7% overall negative emotions. Higher educational level was a protective factor (odds ratio = 0.43) by enhancing self-management and disease understanding, whereas older age, longer treatment duration, comorbidities, poor sleep quality, emotional instability, frequent hepatitis relapses, and severe hepatitis status all elevated the risk of comorbid depression and anxiety. Clinically, early identification of high-risk groups and targeted interventions, such as education-based counseling and sleep management, are crucial for improving mental-health outcomes, although current research heterogeneity from diverse assessment tools and regional sampling indicates the need for standardized broader population studies in the future.
