Randomized Clinical Trial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Sep 19, 2024; 14(9): 1375-1385
Published online Sep 19, 2024. doi: 10.5498/wjp.v14.i9.1375
Effect of quantitative consciousness index on seizure parameters during electroconvulsive therapy in patients with major depressive disorder
Bang-Shu Zhao, Bi Deng, Qi-Bin Chen, Xiao Li, You Yang, Su Min
Bang-Shu Zhao, Qi-Bin Chen, Su Min, Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Bi Deng, You Yang, Department of Anesthesiology, The First Clinical College of Chongqing Medical University, Chongqing 400016, China
Xiao Li, Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Author contributions: Zhao BS prepared the manuscript for publication and contributed to the study design, data collection, and analysis; Deng B and Yang Y contributed to the statistical analysis and preparation of the tables and figures; Li X contributed to the electroshock therapy, psychiatric assessment, and electroencephalography analysis; Chen QB administered anesthesia in clinical practice; Min S contributed to the study design and analysis. All authors revised and approved the final version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 81873798 and No. 81901377; and Chongqing Science and Technology Bureau Under Grant, No. cstc2019jcyj-msxmX0839.
Institutional review board statement: The research was approved by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University, batch number: 2023 Scientific Research Ethics (2023-052).
Clinical trial registration statement: The study was registered on the official website of clinical trials (https://clinicaltrials.gov, ID: NCT05900245).
Informed consent statement: All participants provided informed consent before participating in the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data used in this study can be obtained from the corresponding author upon request.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Su Min, MBBS, Professor, Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. ms89011068@163.com
Received: July 15, 2024
Revised: August 18, 2024
Accepted: August 28, 2024
Published online: September 19, 2024
Processing time: 57 Days and 19.5 Hours
Core Tip

Core Tip: Anesthesia depth based on quantitative consciousness index and quantitative nociceptive index affects electroconvulsive therapy (ECT) seizure parameters during acute ECT in patients with major depressive disorder. Electrical stimulation at a quantitative consciousness index of 60-70 will improve electroencephalography seizure parameters while not increasing complications. The quantitative nociceptive index had a significant effect on post-ictal suppression index, and patients with higher post-ictal suppression index may suffer from greater noxious stimulation during ECT. We should not only consider the effect of sedation depth on the quality of seizure but also the degree of noxious stimulation brought by the treatment technology itself during ECT.