Basic Study
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World J Psychiatry. Mar 19, 2024; 14(3): 445-455
Published online Mar 19, 2024. doi: 10.5498/wjp.v14.i3.445
KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer’s disease
Qun-Shan Lu, Lin Ma, Wen-Jing Jiang, Xing-Bang Wang, Mei Lu
Qun-Shan Lu, Lin Ma, Wen-Jing Jiang, Xing-Bang Wang, Mei Lu, Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Lin Ma, Wen-Jing Jiang, Xing-Bang Wang, Mei Lu, Key Laboratory of Cardiovascular Proteomics of Shandong Province, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Author contributions: Lu QS and Lu M designed the study; Lu QS, Ma L, Jiang WJ, and Wang XB performed the experiments; Lu QS and Lu M wrote the manuscript.
Supported by Natural Science Foundation of Shandong Province, No. ZR2020MH147; and National Natural Science Foundation of China, No. 82002343.
Institutional review board statement: All experiments were performed under the authorization and guidelines of Ethics Committee of Qilu Hospital of Shandong University, No. KYLL-2020 (KS)-102.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Shandong University, No. MDL2021-08-17-02.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Further information and requests for resources and reagents should be directed to and will be fulfilled by the corresponding author at lumei@qiluhospital.com.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mei Lu, MD, Professor, Department of Geriatric Medicine, Qilu Hospital of Shandong University, No. 107 Wenhua Xilu, Jinan 250012, Shandong Province, China. lumei@qiluhospital.com
Received: November 30, 2023
Peer-review started: November 30, 2023
First decision: December 18, 2023
Revised: December 31, 2023
Accepted: February 1, 2024
Article in press: February 1, 2024
Published online: March 19, 2024
Processing time: 110 Days and 2.3 Hours
Core Tip

Core Tip: Type 2 diabetes mellitus (T2D) is closely associated with neurodegenerative diseases, such as Alzheimer’s disease (AD), in which insulin resistance dysfunction plays a critical role. However, the pathological mechanisms underlying diabetes mellitus-related atopic dermatitis remain unclear. Our study demonstrated that the histone acetyltransferase KAT7 ameliorated neuronal death and oxidative stress in AD and restored insulin sensitivity in insulin-resistant neurons by recruiting HMGN1 to enhance the acetylation of the dual-specificity tyrosine phosphorylation-regulated kinase-1A gene, suggesting the promising therapeutic potential of KAT7 in diabetes mellitus-associated AD.