Mechanism of imipenem-induced mental disorder: A meta-analysis

Core Tip

Core Tip: Imipenem is widely used in clinical treatments because of its high efficiency, enzyme resistance, and broad-spectrum antibacterial properties. However, reports of its adverse reactions are increasing daily, among which nervous system adverse reactions are the most common, usually showing symptoms similar to those of nervous system diseases, mental disorders, and aggravating the original nervous system diseases. It has been reported that imipenem can cause insomnia, intermittent delirium and unconsciousness, and its nervous system adverse reactions are related to age, renal insufficiency, hypoxemia, and dosage. Although the adverse effects of imipenem on the nervous system have been recognized in reports both at home and abroad, there is still a lack of in-depth and systematic research on its specific mechanism of causing mental disorders. Owing to the differences in the intervention measures and evaluation methods of different studies, the effectiveness and comprehensiveness of existing research results are limited to some extent. Therefore, this study collected and analyzed relevant literature at home and abroad on imipenem-induced mental disorders and deeply explored its potential mechanism, providing a scientific and comprehensive reference for patients to use drugs safely.